caa a22 4500 465820387 CHVBK 20180323112134.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01233095 doi (NATIONALLICENCE)springer-10.1007/BF01233095 The IL-1 α and β genes are closely linked (<70 kb) on mouse chromosome 2 [Elektronische Daten] [Andrew Silver, Walter Masson, Andrew George, Julia Adam, Roger Cox] The murineIL-1α andIL-1β genes encode structurally and evolutionarily related cytokines that exert a regulatory role in numerous physiological processes including hemopoiesis. Previous studies have shown these genes to be closely linked in the F region of mouse chromosome 2. Here we show, using pulsed-field gel electrophoresis, that theIL-1α and β genes of the CBA/H mouse are very closely linked and contained within a SmaI genomic fragment of ∼70 kb. From conventional and PFGE analyses we suggest thatIL-1β lies 5′ toIL-1α and that the two genes are in the same orientation and separated by ∼50 kb. The apparent clustering of such hemopoietic genes is discussed in relation to evolutionary tandem gene duplication and possible associations with chromosomal fragile sites and leukemogenesis. Plenum Publishing Corporation, 1990 Silver Andrew Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut Masson Walter Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut George Andrew Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut Adam Julia Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut Cox Roger Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/6(1990-11-01), 549-556 0740-7750 16:6<549 1990 16 11188 https://doi.org/10.1007/BF01233095 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01233095 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silver Andrew Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut NATIONALLICENCE 700 1- Masson Walter Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut NATIONALLICENCE 700 1- George Andrew Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut NATIONALLICENCE 700 1- Adam Julia Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut NATIONALLICENCE 700 1- Cox Roger Division of Radiation Oncogenesis, MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, UK aut NATIONALLICENCE 773 0- Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/6(1990-11-01), 549-556 0740-7750 16:6<549 1990 16 11188 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer