caa a22 4500 465820441 CHVBK 20180323112134.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01233097 doi (NATIONALLICENCE)springer-10.1007/BF01233097 The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14 [Elektronische Daten] [C. Hsieh, A. Bowcock, L. Farrer, J. Hebert, K. Huang, L. Cavalli-Sforza, D. Julius, U. Francke] Serotonin (5-hydroxytryptamine) functions as a neurotransmitter and a hormone. Its diverse actions are mediated by at least seven distinct cell surface receptor subtypes. The serotonin receptor subtype 2 (gene symbolHTR2) is a G-protein-coupled receptor, expressed primarily in the cerebral cortex, where upon stimulation it stimulates the hydrolysis of inositol phospholipids. We have mapped theHTR2 locus to human chromosome 13 and to mouse chromosome 14 by somatic cell hybrid analysis. Linkage studies in CEPH families, using a PvuII RFLP detected with the HTR2 probe, revealed tight linkage betweenHTR2 andESD, the locus for esterase D. The most likely position forHTR2 is betweenESD andRB1, the retinoblastoma-1 gene. The homologous loci in mouse,Rb-1 andEsd(Es-10) are on mouse chromosome 14, close toag, agitans, a recessive neurological mutation. Having mappedHtr-2 to mouse chromosome 14, we predict that it falls into this known conserved gene cluster. Plenum Publishing Corporation, 1990 Hsieh C. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut Bowcock A. Department of Genetics, Stanford University Medical Center, 94305, Stanford, California aut Farrer L. Department of Neurology and School of Public Health, Boston, University School of Medicine, 02118, Boston, Massachusetts aut Hebert J. Department of Genetics, Stanford University Medical Center, 94305, Stanford, California aut Huang K. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut Cavalli-Sforza L. Department of Genetics, Stanford University Medical Center, 94305, Stanford, California aut Julius D. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut Francke U. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/6(1990-11-01), 567-574 0740-7750 16:6<567 1990 16 11188 https://doi.org/10.1007/BF01233097 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01233097 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hsieh C. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 700 1- Bowcock A. Department of Genetics, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 700 1- Farrer L. Department of Neurology and School of Public Health, Boston, University School of Medicine, 02118, Boston, Massachusetts aut NATIONALLICENCE 700 1- Hebert J. Department of Genetics, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 700 1- Huang K. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 700 1- Cavalli-Sforza L. Department of Genetics, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 700 1- Julius D. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 700 1- Francke U. Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California aut NATIONALLICENCE 773 0- Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/6(1990-11-01), 567-574 0740-7750 16:6<567 1990 16 11188 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer