caa a22 4500 465820735 CHVBK 20180323112135.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01233198 doi (NATIONALLICENCE)springer-10.1007/BF01233198 Pyruvate dehydrogenase E1α subunit genes in the mouse: Mapping and comparison with human homologs [Elektronische Daten] [R. Brown, H-H. Dahl, G. Brown] Two gene loci for the E1α subunit of the pyruvate dehydrogenase (PDH) complex have been mapped in the mouse by in situ hybridization. One locus maps to the X chromosome in the region F3-F4, the other to chromosome 19, in band B close to the centromere. This arrangement is exactly comparable to the situation in man where there is an X-linked PDH E1α locus and an autosomal locus on chromosome 4. Comparison of the regional localization of the human and mouse X-linked PDH E1α genes provides further information concerning sites of rearrangement of segments of the X chromosome during mammalian evolution. The human autosomal PDH E1α gene is a "processed” gene, which lacks the introns that are present in the X-linked gene. It codes for a testis-specific E1α subunit that is only expressed after the onset of spermatogenesis. The comparative mapping results in the mouse suggest that the genetic organization and pattern of expression of the two PDH E1α genes is the same in the two species. Plenum Publishing Corporation, 1990 Brown R. Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia aut Dahl H-H Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia aut Brown G. Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia aut Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/5(1990-09-01), 487-492 0740-7750 16:5<487 1990 16 11188 https://doi.org/10.1007/BF01233198 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01233198 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brown R. Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia aut NATIONALLICENCE 700 1- Dahl H-H Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia aut NATIONALLICENCE 700 1- Brown G. Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia aut NATIONALLICENCE 773 0- Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/5(1990-09-01), 487-492 0740-7750 16:5<487 1990 16 11188 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer