caa a22 4500 465821812 CHVBK 20180323112137.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00047550 doi (NATIONALLICENCE)springer-10.1007/BF00047550 On the possible effects of homeostatic shifts in human embryonic development [Elektronische Daten] [J. Chela-Flores, C. Espejo Acuiña] Possible etiological factors of congenital malformations as well as of human trisomies are considered in the framework of the repressor hypothesis. In this approach gene expression is envisaged from the point of view of the functional variations of the total activation energy for normal gene expression in homeostatic equilibrium. We restrict our attention to variations of the total activation energy under the effect of temperature gradients. We discuss the evidence that hyperthermia may be an etiological factor for trisomies in humans. Kluwer Academic Publishers, 1990 Congenital nationallicence malformations nationallicence Development nationallicence Genetic expression nationallicence Hyperthermia nationallicence Repressor hypothesis nationallicence Trisomies nationallicence Chela-Flores J. International Centre for Theoretical Physics, Trieste, Italy aut Espejo Acuiña C. Hospital Universitario de Caracas, Universidad Central de Venezuela, Ciudad Universitaria, Caracas, Venezuela aut Acta Biotheoretica Kluwer Academic Publishers 38/2(1990-06-01), 135-142 0001-5342 38:2<135 1990 38 10441 https://doi.org/10.1007/BF00047550 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00047550 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chela-Flores J. International Centre for Theoretical Physics, Trieste, Italy aut NATIONALLICENCE 700 1- Espejo Acuiña C. Hospital Universitario de Caracas, Universidad Central de Venezuela, Ciudad Universitaria, Caracas, Venezuela aut NATIONALLICENCE 773 0- Acta Biotheoretica Kluwer Academic Publishers 38/2(1990-06-01), 135-142 0001-5342 38:2<135 1990 38 10441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer