caa a22 4500 465822169 CHVBK 20180323112138.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00164738 doi (NATIONALLICENCE)springer-10.1007/BF00164738 Growth and product formation of actinomycetes cultivated at increased total pressure and oxygen partial pressure [Elektronische Daten] [Ekkehard Liefke, Dieter Kaiser, Ulfert Onken] Summary: Influence of pressure (P) and oxygen partial pressure ( $$P_{O_2 }$$ ) on cultivation of various Streptomyces spp. and Micromonospora purpurea was examined in pressurized air-lift and stirred tank fermenters. The maximum $$P_{O_2 }$$ was 2100 mbar. Growth and product formation of all cultures tested were markedly influenced by $$P_{O_2 }$$ higher than 1000 mbar. There is evidence that wild strains are more oxygen tolerant than production strains. At a certain $$P_{O_2 }$$ the metabolic activities of all cultures were inhibited. However, results obtained with S. aureofaciens and S. rimosus indicated an increase in specific product formation rate at elevated pressure. With increase in oxygen tension incorporation of oxygen into tetracycline molecules was enhanced. Since elevated oxygen tension can either show inhibiting effects or may be used for regulation of product formation and selectivity, the influence of $$P_{O_2 }$$ should be determined in an appropriate experimental set-up for each process. Springer-Verlag, 1990 Liefke Ekkehard Lehrstuhl Technische Chemie B, Universität Dortmund, Emil-Figge-Strasse 66, D-4600, Dortmund 50, Federal Republic of Germany aut Kaiser Dieter Lehrstuhl Technische Chemie B, Universität Dortmund, Emil-Figge-Strasse 66, D-4600, Dortmund 50, Federal Republic of Germany aut Onken Ulfert Lehrstuhl Technische Chemie B, Universität Dortmund, Emil-Figge-Strasse 66, D-4600, Dortmund 50, Federal Republic of Germany aut Applied Microbiology and Biotechnology Springer-Verlag 32/6(1990-03-01), 674-679 0175-7598 32:6<674 1990 32 253 https://doi.org/10.1007/BF00164738 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00164738 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liefke Ekkehard Lehrstuhl Technische Chemie B, Universität Dortmund, Emil-Figge-Strasse 66, D-4600, Dortmund 50, Federal Republic of Germany aut NATIONALLICENCE 700 1- Kaiser Dieter Lehrstuhl Technische Chemie B, Universität Dortmund, Emil-Figge-Strasse 66, D-4600, Dortmund 50, Federal Republic of Germany aut NATIONALLICENCE 700 1- Onken Ulfert Lehrstuhl Technische Chemie B, Universität Dortmund, Emil-Figge-Strasse 66, D-4600, Dortmund 50, Federal Republic of Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 32/6(1990-03-01), 674-679 0175-7598 32:6<674 1990 32 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer