caa a22 4500 46582255X CHVBK 20180323112139.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00173717 doi (NATIONALLICENCE)springer-10.1007/BF00173717 Ambruticin S production in amino acid rich media [Elektronische Daten] [N. Hopf, S. Yonsel, W. Deckwer] Summary: The antimycoticum ambruticin was produced by cultivating the myxobacterium Sorangium cellulosum in shake flasks and stirred tank reactors with 10- and 30-1 working volumes. During growth and product formation amino acid concentrations in the complex media were measured by HPLC. In the logarithmic growth phase free aspartate and glutamate were assimilated without product formation. After consumption of aspartate and glutamate, growth was limited and ambruticin production set in. The effects of biological parameters such as age, amount of inoculum, pretreatment of cells before inoculation and time of precultivation were also investigated. Springer-Verlag, 1990 Hopf N. Biochemical Engineering Division, GBF — Gesellschaft für Biotechnologische Forschunf mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic of Germany aut Yonsel S. Biochemical Engineering Division, GBF — Gesellschaft für Biotechnologische Forschunf mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic of Germany aut Deckwer W. Biochemical Engineering Division, GBF — Gesellschaft für Biotechnologische Forschunf mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic of Germany aut Applied Microbiology and Biotechnology Springer-Verlag 32/5(1990-02-01), 499-504 0175-7598 32:5<499 1990 32 253 https://doi.org/10.1007/BF00173717 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00173717 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hopf N. Biochemical Engineering Division, GBF — Gesellschaft für Biotechnologische Forschunf mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic of Germany aut NATIONALLICENCE 700 1- Yonsel S. Biochemical Engineering Division, GBF — Gesellschaft für Biotechnologische Forschunf mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic of Germany aut NATIONALLICENCE 700 1- Deckwer W. Biochemical Engineering Division, GBF — Gesellschaft für Biotechnologische Forschunf mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic of Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 32/5(1990-02-01), 499-504 0175-7598 32:5<499 1990 32 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer