caa a22 4500 46582272X CHVBK 20180323112140.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00170913 doi (NATIONALLICENCE)springer-10.1007/BF00170913 Effects of oxygen supply on the production of nikkomycin with immobilized cells of Streptomyces tendae [Elektronische Daten] [H. Uwe Trück, Horst Chmiel, Walter Hammes, Walter Trösch] Summary: For continuous production of the antibiotic nikkomycin immobilized cells have been used in a fluidized bed bioreactor. Cells of Streptomyces tendae were immobilized on sintered glass particles. Different biomass concentrations on the particles correspond to different thicknesses of mycelial layers because growth occurs only on the outer surface of the particles. The antibiotic productivity decreased with increasing layer thickness. In fermentations with higher concentrations of both biomass on the particles and dissolved oxygen levels of about 70% the productivity was also limited because of limited oxygen diffusion in the layers. Springer-Verlag, 1990 Uwe Trück H. Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut Chmiel Horst Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut Hammes Walter Institut für Lebensmitteltechnologie, Universität Hohenheim, Garbenstrasse 25, D-7000, Stuttgart 70, Federal Republic of Germany aut Trösch Walter Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut Applied Microbiology and Biotechnology Springer-Verlag 34/1(1990-10-01), 1-4 0175-7598 34:1<1 1990 34 253 https://doi.org/10.1007/BF00170913 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170913 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uwe Trück H. Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut NATIONALLICENCE 700 1- Chmiel Horst Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hammes Walter Institut für Lebensmitteltechnologie, Universität Hohenheim, Garbenstrasse 25, D-7000, Stuttgart 70, Federal Republic of Germany aut NATIONALLICENCE 700 1- Trösch Walter Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 34/1(1990-10-01), 1-4 0175-7598 34:1<1 1990 34 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer