caa a22 4500 465823661 CHVBK 20180323112142.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00170560 doi (NATIONALLICENCE)springer-10.1007/BF00170560 Kautola Helena Laboratory of Biotechnology and Food Engineering, Helsinki University of Technology, SF-02150, Espoo, Finland aut Itaconic acid production from xylose in repeated-batch and continuous bioreactors [Elektronische Daten] [Helena Kautola] Summary: Itaconic acid production from xylose by immobilized Aspergillus terreus TKK 200-5-2 mycelia was optimized both in repeated shake-flask fermentations and in continuous column bioreactors using statistical experimental design and empirical modelling. Using continuous 9-1 scale air-lift bioreactors, a pH of 2.5, aeration rate of 0.6 v/v per minute and residence time of 160 h gave the highest itaconic acid concentration. In air-lift bioreactors a cubic carrier size of 0.5 cm gave a 3.3-fold higher product concentration than 1-cm cubes. Packed-bed column reactors had a higher production rate than air-lift reactors. Springer-Verlag, 1990 Applied Microbiology and Biotechnology Springer-Verlag 33/1(1990-04-01), 7-11 0175-7598 33:1<7 1990 33 253 https://doi.org/10.1007/BF00170560 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00170560 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kautola Helena Laboratory of Biotechnology and Food Engineering, Helsinki University of Technology, SF-02150, Espoo, Finland aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 33/1(1990-04-01), 7-11 0175-7598 33:1<7 1990 33 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer