caa a22 4500 465823912 CHVBK 20180323112143.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00604929 doi (NATIONALLICENCE)springer-10.1007/BF00604929 Asymmetric amination of 4-methoxyphenylacetone and its related compounds with microorganisms [Elektronische Daten] [Katsuhiko Nakamichi, Takeji Shibatani, Yoko Yamamoto, Tadashi Sato] Summary: Asymmetric amination of 4-methoxyphenylacetone and its related compounds by microorganisms was investigated. Among 630 type culture strains, 4-methoxyphenylacetone-aminating ability was found inBrevibacterium, Chromobacterium, Flavobacterium, Mycobacterium, Pseudomonas, andSarcina spp. 4-Methoxyamphetamine produced by these microorganisms was the (S)-(+)-enantiomer.B. linens IFO 12141 was selected as the best strain. The optimum pH of amination was about 7.0, andl-alanine was the most effective aminov donor for the amination. By using this strain, 37.6 mM (S)-(+)-4-methoxyamphetamine was formed with a 94% conversion yield from 4-methoxyphenylacetone. As for substrate specificity,B. linens IFO 12141 catalysed amination of 3,4-dimethoxyphenylacetone and 4-(4-methoxyphenyl)-2-butanone, and formed the corresponding optically active amines. Springer-Verlag, 1990 Nakamichi Katsuhiko Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut Shibatani Takeji Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut Yamamoto Yoko Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut Sato Tadashi Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut Applied Microbiology and Biotechnology Springer-Verlag 33/6(1990-09-01), 637-640 0175-7598 33:6<637 1990 33 253 https://doi.org/10.1007/BF00604929 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00604929 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakamichi Katsuhiko Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut NATIONALLICENCE 700 1- Shibatani Takeji Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut NATIONALLICENCE 700 1- Yamamoto Yoko Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut NATIONALLICENCE 700 1- Sato Tadashi Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 33/6(1990-09-01), 637-640 0175-7598 33:6<637 1990 33 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer