caa a22 4500 465824390 CHVBK 20180323112145.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00176660 doi (NATIONALLICENCE)springer-10.1007/BF00176660 Pigmented variants of Tolypocladium inflatum in relation to cyclosporin A production [Elektronische Daten] [Teija Aarnio, Spiros Agathos] Summary: We have isolated four distinct colony types of the fungus Tolypocladium inflatum, the producer of the immunosuppresive agent cyclosporin A: morphologically normal white, red, and orange colonies and morphologically diverse tiny brown colonies. In liquid cultures, white normal and brown colonies developed into yellow broths. The broth of the brown colony had a low final pH and low cyclosporin production, whereas orange and red colonies had dark brown and even black broths with higher final pH and high cyclosporin production. The specific production of cyclosporin A by the red colony was three times that of the white normal colonies. Springer-Verlag, 1990 Aarnio Teija Department of Chemical and Biochemical Engineering, Rutgers University, The State University of New Jersey, P.O. Box 909, 08855-0909, Piscataway, NJ, USA aut Agathos Spiros Department of Chemical and Biochemical Engineering, Rutgers University, The State University of New Jersey, P.O. Box 909, 08855-0909, Piscataway, NJ, USA aut Applied Microbiology and Biotechnology Springer-Verlag 33/4(1990-07-01), 435-437 0175-7598 33:4<435 1990 33 253 https://doi.org/10.1007/BF00176660 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176660 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aarnio Teija Department of Chemical and Biochemical Engineering, Rutgers University, The State University of New Jersey, P.O. Box 909, 08855-0909, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Agathos Spiros Department of Chemical and Biochemical Engineering, Rutgers University, The State University of New Jersey, P.O. Box 909, 08855-0909, Piscataway, NJ, USA aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 33/4(1990-07-01), 435-437 0175-7598 33:4<435 1990 33 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer