caa a22 4500 465824757 CHVBK 20180323112146.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00176512 doi (NATIONALLICENCE)springer-10.1007/BF00176512 Butyrate production in continuous culture of Clostridium tyrobutyricum: effect of end-product inhibition [Elektronische Daten] [D. Michel-Savin, R. Marchal, J. Vandecasteele] Summary: Production of butyrate has been studied in continuous cultures of Clostridium tyrobutyricum. Production of acids, gases and cell biomass were determined under conditions of glucose limitation by varying either the glucose input or the dilution rate. Addition of acetate or butyrate to the cultures was also tested. The results led to the proposition that inhibition by acids acting as incouplers of energy production could provide a physiological explanation for most of the phenomena observed. It readily accounted for the higher productivities but lower product concentrations obtained in continuous culture with respect to batch or fed-batch conditions. It also explained the decrease in the ratios of butyrate to total acids and in cell yield observed at higher glucose input as well as the behaviour of the cultures under conditions of excess glucose. It could also possibly account for the partial conversion of added acetate to butyrate observed at moderate growth rates. Springer-Verlag, 1990 Michel-Savin D. Direction de Recherche Biotechnologie et Environnement, Institut Français du Pétrole, F-92506, Rueil-Malmaison, France aut Marchal R. Direction de Recherche Biotechnologie et Environnement, Institut Français du Pétrole, F-92506, Rueil-Malmaison, France aut Vandecasteele J. Direction de Recherche Biotechnologie et Environnement, Institut Français du Pétrole, F-92506, Rueil-Malmaison, France aut Applied Microbiology and Biotechnology Springer-Verlag 33/2(1990-05-01), 127-131 0175-7598 33:2<127 1990 33 253 https://doi.org/10.1007/BF00176512 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176512 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Michel-Savin D. Direction de Recherche Biotechnologie et Environnement, Institut Français du Pétrole, F-92506, Rueil-Malmaison, France aut NATIONALLICENCE 700 1- Marchal R. Direction de Recherche Biotechnologie et Environnement, Institut Français du Pétrole, F-92506, Rueil-Malmaison, France aut NATIONALLICENCE 700 1- Vandecasteele J. Direction de Recherche Biotechnologie et Environnement, Institut Français du Pétrole, F-92506, Rueil-Malmaison, France aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 33/2(1990-05-01), 127-131 0175-7598 33:2<127 1990 33 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer