caa a22 4500 465824846 CHVBK 20180323112146.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00176514 doi (NATIONALLICENCE)springer-10.1007/BF00176514 A study of N- and P-dependence of nikkomycin production in continuous culture with immobilized cells [Elektronische Daten] [H. Trück, Horst Chmiel, Walter Hammes, Walter Trösch] Summary: The influence of nitrogen and phosphate on the biosynthesis of nikkomycin was studied in chemically defined medium. Cells of Streptomyces tendae were immobilized on porous glass particles in a fluidized-bed reactor for continuous production of nikkomycin. Phosphate had no significant influence on the biosynthesis of nikkomycin. However, even a very low concentration of phosphate in the production medium (00.0125 mmol/l) resulted in microbial growth on the particles. The concentration of nitrogen was highly effective in the regulation of the biosynthesis of nikkomycin. A high level of antibiotic production (maximum 3.05 mg/g dry cell weight per hour) was maintained for a period of about 200 h in a medium that contained nitrogen at a concentration of 0.2 g NH4NO3/l. Springer-Verlag, 1990 Trück H. Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut Chmiel Horst Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut Hammes Walter Institut für Lebensmitteltechnologie, Universität Hohenheim, Garbenstrasse 25, D-7000, Stuttgart 70, Federal Republic of Germany aut Trösch Walter Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut Applied Microbiology and Biotechnology Springer-Verlag 33/2(1990-05-01), 139-144 0175-7598 33:2<139 1990 33 253 https://doi.org/10.1007/BF00176514 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176514 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trück H. Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut NATIONALLICENCE 700 1- Chmiel Horst Lehrstuhl für Bioprozesstechnik, Universität Stuttgart, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hammes Walter Institut für Lebensmitteltechnologie, Universität Hohenheim, Garbenstrasse 25, D-7000, Stuttgart 70, Federal Republic of Germany aut NATIONALLICENCE 700 1- Trösch Walter Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik, Nobelstrasse 12, D-7000, Stuttgart 80, Federal Republic of Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 33/2(1990-05-01), 139-144 0175-7598 33:2<139 1990 33 253 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer