caa a22 4500 465826121 CHVBK 20180323112149.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02828293 doi (NATIONALLICENCE)springer-10.1007/BF02828293 Progress in the development of a fluorescent intravascular blood gas system in man [Elektronische Daten] [C. Mahutte, Catherine Sassoon, JesÚs Muro, Douglas Hansmann, Thomas Maxwell, William Miller, Masao Yafuso] In vitro and in vivo animal studies have shown accurate measurements of arterial blood pH (pHa), carbon dioxide tension (PaCO2), and oxygen tension (PaO2) with small intravascular fluorescent probes. Initial human clinical studies showed unexplained intermittent large drops in sensor oxygen tension (PiO2). Normal volunteers were studied to elucidate this problem. In the first part of this study, the probe and cannula were manipulated and the probe configuration and its position within the cannula were varied. The decreases in PiO2 were judged to be primarily due to the sensor touching the arterial wall. Retraction of the sensor tip within the cannula eliminated the problem. In the second part of this study, the accuracy of the retracted probe was evaluated in 4 subjects who breathed varying fractions of inspired oxygen and carbon dioxide. The arterial ranges achieved were 7.20 to 7.59 for pH, 22 to 70 mm Hg for PaCO2, and 46 to 633 mm Hg for PaO2. Linear regression of 48 paired sensor (i) versus arterial values showed pHi = 0.896 pHa + 0.773 (r = 0.98, SEE = 0.017); PiCO2 = 1.05 PaCO2-1.33 (r = 0.98, SEE = 2.4 mm Hg); and PiO2 = 1.09 PaO2-20.6 (r = 0.99, SEE = 21.2 mm Hg). Bias (defined as the mean differences between sensor and arterial values) and precision (SD of differences) were, respectively, -0.003 and 0.02 tor pHi, 0.77 and 2.44 mm Hg for PiCO2, and -2.9 and 25.4 mm Hg for PiO2. The mean in vivo 90% response times for step changes in inspired gas were 2.64, 3.88, and 2.60 minutes, respectively, for pHi, PiCO2, and PiO2. Little, Brown and Company, 1990 Equipment: fiberoptic sensors nationallicence Blood gas analysis nationallicence Monitoring nationallicence Mahutte C. Department of Medicine, Long Beach, Veterans Administration Medical Center, Long Beach, CA aut Sassoon Catherine Department of Medicine, Long Beach, Veterans Administration Medical Center, Long Beach, CA aut Muro JesÚs Department of Medicine, Long Beach, Veterans Administration Medical Center, Long Beach, CA aut Hansmann Douglas Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut Maxwell Thomas Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut Miller William Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut Yafuso Masao Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut Journal of Clinical Monitoring Springer Netherlands 6/2(1990-04-01), 147-157 0748-1977 6:2<147 1990 6 10877 https://doi.org/10.1007/BF02828293 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02828293 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mahutte C. Department of Medicine, Long Beach, Veterans Administration Medical Center, Long Beach, CA aut NATIONALLICENCE 700 1- Sassoon Catherine Department of Medicine, Long Beach, Veterans Administration Medical Center, Long Beach, CA aut NATIONALLICENCE 700 1- Muro JesÚs Department of Medicine, Long Beach, Veterans Administration Medical Center, Long Beach, CA aut NATIONALLICENCE 700 1- Hansmann Douglas Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut NATIONALLICENCE 700 1- Maxwell Thomas Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut NATIONALLICENCE 700 1- Miller William Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut NATIONALLICENCE 700 1- Yafuso Masao Cardiovascular Devices, Inc, 3M Health Care, Irvine, CA aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring Springer Netherlands 6/2(1990-04-01), 147-157 0748-1977 6:2<147 1990 6 10877 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer