caa a22 4500 465826407 CHVBK 20180323112150.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00258757 doi (NATIONALLICENCE)springer-10.1007/BF00258757 Dietary sodium, glomerular filtration rate autoregulation, and glomerular size distribution profiles in domestic fowl ( Gallus gallus ) [Elektronische Daten] [Vincent Vena, Tri Lac, Robert Wideman Jr.] Summary: Mammalian glomerular filtration rate (GFR) autoregulation can be impaired by protocols that inhibit tubuloglomrular feedback, such as high sodium intake. Domestic fowl were fed diets containing either high sodium (0.39% Na: High-Na Group) or low sodium (0.03% Na: Low-Na Group). An arterial snare was used to reduce renal arterial perfusion pressure (RAPP) in a stepwise fashion to evaluate GFR autoregulation. Absolute sodium excretion, fractional sodium excretion (FENa), and ambient systemic arterial blood pressure were significantly elevated in the High-Na Group when compared with the Low-Na Group, and pressure natriuresis was abolished by the Low-Na diet. However, GFR autoregulatory profiles were identical in birds fed High-Na and Low-Na diets, suggesting that tubuloglomerular feed-back does not contribute significantly to avian GFR autoregulation. Filtering glomeruli were stained in vivo with alcian blue dye to determine if RAPP-induced reductions in GFR are associated with cessation of filtration (glomerular intermittency) by a portion of the nephron population. RAPP was held below the GFR autoregulatory range (experimental group) or was at ambient systemic arterial pressure (control group) during glomerular staining. Reducing RAPP below the autoregulatory range reduced GFR by 50%, but similar glomerular size distribution profiles were observed for experimental and control groups. These results indicate that sustained glomerular intermittency does not contribute to the decrease in GFR when RAPP is reduced below the autoregulatory range. Springer-Verlag, 1990 Renal hemodynamics nationallicence Urine concentration nationallicence Kidney function nationallicence BW : body weight nationallicence C : control nationallicence E : excretion nationallicence FE : fractional excretion nationallicence FF : filtration fraction nationallicence GFR : glomerular filtration rate nationallicence PAH : p-amino hippuric acid nationallicence RAPP : renal arterial perfusion pressure nationallicence RPF : renal plasma flow nationallicence RT : reptilian-type nationallicence SNGFR : single nephron glomerular filtration rate nationallicence U OSM : urine osmolarity nationallicence UFR : urine flow rate nationallicence Vena Vincent Department of Poultry Science, The Pennsylvania State University, 16802, University Park, PA, USA aut Lac Tri Department of Poultry Science, The Pennsylvania State University, 16802, University Park, PA, USA aut Wideman Jr. Robert Department of Poultry Science, The Pennsylvania State University, 16802, University Park, PA, USA aut Journal of Comparative Physiology B Springer-Verlag 160/1(1990-04-01), 7-16 0174-1578 160:1<7 1990 160 360 https://doi.org/10.1007/BF00258757 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00258757 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vena Vincent Department of Poultry Science, The Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Lac Tri Department of Poultry Science, The Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Wideman Jr Robert Department of Poultry Science, The Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 773 0- Journal of Comparative Physiology B Springer-Verlag 160/1(1990-04-01), 7-16 0174-1578 160:1<7 1990 160 360 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer