caa a22 4500 465826504 CHVBK 20180323112150.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00302594 doi (NATIONALLICENCE)springer-10.1007/BF00302594 Autonomic nervous control of blood pressure and heart rate during hypoxia in the cod, Gadus morhua [Elektronische Daten] [Regina Fritsche, Stefan Nilsson] Summary: The autonomic nervous and possible adrenergic humoral control of blood pressure and heart rate during hypoxia was investigated in Atlantic cod. The oxygen tension in the water was reduced to 4.0-5.3 kPa (i.e.. PwO2=30-40 mmHg), and the fish responded with an immediate increase in ventral and dorsal aortic blood pressure (P va P da), as well as a slowly developing bradycardia. The plasma concentrations of circulating catecholamines increased during hypoxia with a peak in the plasma level of noradrenaline occurring before the peak for adrenaline. Bretylium was used as a chemical tool to differentiate between neuronal and humoral adrenergic control of blood pressure and heart rate (f H) during hypoxia. The increase in P va and P da in response to hypoxia was strongly reduced in bretylium-treated cod, which suggests that adrenergic nerves are responsible for hypoxic hypertension. In addition, a small contribution by circulating catecholamines to the adrenergic tonus affecting P va during hypoxia was suggested by the decrease in P va induced by injection of the α-adrenoceptor antagonist phentolamine. The cholinergic and the adrenergic tonus affecting heart rate were estimated by injections of atropine and the β-adrenoceptor antagonist sotalol. The experiments demonstrate an increased cholicholinergic as well as adrenergic tonus on the heart during hypoxia. Springer-Verlag, 1990 Gadus morhua nationallicence Teleost nationallicence Hypoxia nationallicence Autonomic nervous system nationallicence Cardiovascular control nationallicence Fritsche Regina Comparative Neuroscience Unit, Department of Zoophysiology, University of Göteborg, PO Box 250 59, S-400 31, Göteborg, Sweden aut Nilsson Stefan Comparative Neuroscience Unit, Department of Zoophysiology, University of Göteborg, PO Box 250 59, S-400 31, Göteborg, Sweden aut Journal of Comparative Physiology B Springer-Verlag 160/3(1990-08-01), 287-292 0174-1578 160:3<287 1990 160 360 https://doi.org/10.1007/BF00302594 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00302594 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fritsche Regina Comparative Neuroscience Unit, Department of Zoophysiology, University of Göteborg, PO Box 250 59, S-400 31, Göteborg, Sweden aut NATIONALLICENCE 700 1- Nilsson Stefan Comparative Neuroscience Unit, Department of Zoophysiology, University of Göteborg, PO Box 250 59, S-400 31, Göteborg, Sweden aut NATIONALLICENCE 773 0- Journal of Comparative Physiology B Springer-Verlag 160/3(1990-08-01), 287-292 0174-1578 160:3<287 1990 160 360 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer