caa a22 4500 465826660 CHVBK 20180323112151.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01075667 doi (NATIONALLICENCE)springer-10.1007/BF01075667 Performance of the isolated and perfused working heart of the teleost Conger conger [Elektronische Daten] study of the inotropic effect of prostacyclin [Raffaele Acierno, Claudio Agnisola, Rita Venzi, Bruno Tota] Summary: An in vitro preparation of the heart of the teleostConger conger, isolated without the pericardium, was set up. The procedure allowed subambient pressures to develop in the perfusion chamber during contraction, mimicking the in vivo situation with the pericardium intact. The ventricle produced a cardiac output of about 15 ml·min-1·kg wet body weight-1 at subambient input pressure, and was able to double the stroke work with an increase of preload up to about 0.2 kPa. Using this preparation it was found that prostacyclin has a positive inotropic effect on the atrium and ventricle, but it does not affect the heart rate. Semilogarithmic doseresponse curves of prostacyclin on the atrium are reported, showing a threshold concentration of about 10-9 M. The isolated and perfusedConger conger heart provides a useful model for a detailed analysis of the action of prostacyclin on myocardial contractility. Springer-Verlag, 1990 Conger eel nationallicence heart nationallicence In vitro performance Prostacyclin nationallicence Myocardial contractility nationallicence Acierno Raffaele Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut Agnisola Claudio Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut Venzi Rita Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut Tota Bruno Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut Journal of Comparative Physiology B Springer-Verlag 160/4(1990-07-01), 365-371 0174-1578 160:4<365 1990 160 360 https://doi.org/10.1007/BF01075667 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01075667 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Acierno Raffaele Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut NATIONALLICENCE 700 1- Agnisola Claudio Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut NATIONALLICENCE 700 1- Venzi Rita Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut NATIONALLICENCE 700 1- Tota Bruno Stazione Zoologica "A. Dohrn”, I-80121, Napoli, Italy aut NATIONALLICENCE 773 0- Journal of Comparative Physiology B Springer-Verlag 160/4(1990-07-01), 365-371 0174-1578 160:4<365 1990 160 360 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer