caa a22 4500 467881758 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0524-4 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0524-4 Arshavsky Y. I. Institute for Nonlinear Science, University of California San Diego, La Jolla, CA, USA aut Alzheimer's disease, brain immune privilege and memory: a hypothesis [Elektronische Daten] [Y. I. Arshavsky] Summary.: The most distinctive feature of Alzheimer's disease (AD) is the specific degeneration of the neurons involved in memory consolidation, storage, and retrieval. Patients suffering from AD forget basic information about their past, loose linguistic and calculative abilities and communication skills. Thus, understanding the etiology of AD may provide insights into the mechanisms of memory and vice versa. The brain is an immunologically privileged site protected from the organism's immune reactions by the blood-brain barrier (BBB). All risk factors for AD (both cardiovascular and genetic) lead to destruction of the BBB. Evidence emerging from recent literature indicates that AD may have an autoimmune nature associated with BBB impairments. This hypothesis suggests that the process of memory consolidation involves the synthesis of novel macromolecules recognized by the immune system as "non-self” antigens. The objective of this paper is to stimulate new approaches to studies of neural mechanisms underpinning memory consolidation and its breakdown during AD. If the hypothesis on the autoimmune nature of AD is correct, the identification of the putative antigenic macromolecules might be critical to understanding the etiology and prevention of AD, as well as for elucidating cellular mechanisms of learning and memory. Springer-Verlag, 2006 Keywords: Alzheimer's disease, immune privilege, blood-brain barrier, autoimmunity, declarative memory nationallicence Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1697-1707 0300-9564 113:11<1697 2006 113 702 https://doi.org/10.1007/s00702-006-0524-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0524-4 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Arshavsky Y. I. Institute for Nonlinear Science, University of California San Diego, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1697-1707 0300-9564 113:11<1697 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer