caa a22 4500 467881766 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0528-0 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0528-0 Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus [Elektronische Daten] [S. Yoshida, M. Maeda, S. Kaku, H. Ikeya, K. Yamada, S. Nakaike] Summary.: It has been pointed out that hyperphosphorylation of microtubule-associated protein tau caused by stress might participate in the early stages of Alzheimer's disease pathogenesis. In the present study, we investigated the effects of cold water stress (CWS) on tau phosphorylation in the mouse hippocampus and the effects of GSK-3β inhibitor, LiCl, on CWS-induced changes in tau phosphorylation levels by immunoblot analyses. CWS exposure caused an increase in tau phosphorylation at the Tau-1 (Ser199/202), AT8 (Ser202/Thr205) and Ser396 sites. CWS-induced changes in tau phosphorylation at the Ser199/202 and Ser396, but not at Ser202/Thr205, were significantly attenuated by LiCl pretreatment. Total tau levels also showed a decided tendency to increase after CWS, which tendency was also countered by LiCl. Finally, we showed that CWS increased the active form of GSK-3β that was phosphorylated at Tyr216. These results suggest that a CWS-induced increase in phosphorylated tau in the hippocampus is mediated, at least partly, by the activation of GSK-3β. Springer-Verlag, 2006 Keywords: Stress, tau phosphorylation, GSK-3β, lithium nationallicence Yoshida S. Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut Maeda M. Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut Kaku S. Medicinal Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD, Saitam, Japan aut Ikeya H. Lead Generation Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut Yamada K. Laboratory of Neuropsychopharmacology, Kanazawa University Graduate School of Natural Science & Technology, Kakuma-machi, Kanazawa, Japan aut Nakaike S. Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1803-1814 0300-9564 113:11<1803 2006 113 702 https://doi.org/10.1007/s00702-006-0528-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0528-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshida S. Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut NATIONALLICENCE 700 1- Maeda M. Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut NATIONALLICENCE 700 1- Kaku S. Medicinal Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD, Saitam, Japan aut NATIONALLICENCE 700 1- Ikeya H. Lead Generation Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut NATIONALLICENCE 700 1- Yamada K. Laboratory of Neuropsychopharmacology, Kanazawa University Graduate School of Natural Science & Technology, Kakuma-machi, Kanazawa, Japan aut NATIONALLICENCE 700 1- Nakaike S. Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., LTD., Saitam, Japan aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1803-1814 0300-9564 113:11<1803 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer