caa a22 4500 467881774 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0575-6 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0575-6 The significance of neuroinflammation in understanding Alzheimer's disease [Elektronische Daten] [P. Eikelenboom, R. Veerhuis, W. Scheper, A. J. M. Rozemuller, W. A. van Gool, J. J. M. Hoozemans] Summary.: The interest of scientists in the involvement of inflammation-related mechanisms in the pathogenesis of Alzheimer's disease (AD) goes back to the work of one of the pioneers of the study of this disease. About hundred years ago Oskar Fischer stated that the crucial step in the plaque formation is the extracellular deposition of a foreign substance that provokes an inflammatory reaction followed by a regenerative response of the surrounding nerve fibers. Eighty years later immunohistochemical studies revealed that amyloid plaques are indeed co-localized with a broad variety of inflammation-related proteins (complement factors, acute-phase proteins, pro-inflammatory cytokines) and clusters of activated microglia. These findings have led to the view that the amyloid plaque is the nidus of a non-immune mediated chronic inflammatory response locally induced by fibrillar Aβ deposits. Recent neuropathological studies show a close relationship between fibrillar Aβ deposits, inflammation and neuroregeneration in relatively early stages of AD pathology preceding late AD stages characterized by extensive tau-related neurofibrillary changes. In the present work we will review the role of inflammation in the early stage of AD pathology and particularly the role of inflammation in Aβ metabolism and deposition. We also discuss the possibilities of inflammation-based therapeutic strategies in AD. Springer-Verlag, 2006 Keywords: Alzheimer's disease, neuroinflammation, microglia, acute-phase proteins, Aβ-associated proteins nationallicence Eikelenboom P. Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands aut Veerhuis R. Department of Psychiatry, Vrije Universiteit Medical Center, The Netherlands aut Scheper W. Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands aut Rozemuller A. J. M. Department of Pathology, Vrije Universiteit Medical Center, The Netherlands aut van Gool W. A. Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands aut Hoozemans J. J. M. Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1685-1695 0300-9564 113:11<1685 2006 113 702 https://doi.org/10.1007/s00702-006-0575-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0575-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eikelenboom P. Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Veerhuis R. Department of Psychiatry, Vrije Universiteit Medical Center, The Netherlands aut NATIONALLICENCE 700 1- Scheper W. Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Rozemuller A. J. M. Department of Pathology, Vrije Universiteit Medical Center, The Netherlands aut NATIONALLICENCE 700 1- van Gool W. A. Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Hoozemans J. J. M. Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1685-1695 0300-9564 113:11<1685 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer