caa a22 4500 467881790 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0574-7 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0574-7 Auditory event-related potentials in subcortical vascular cognitive impairment and in Alzheimer's disease [Elektronische Daten] [E. G. Muscoso, E. Costanzo, O. Daniele, D. Maugeri, E. Natale, G. Caravaglios] Summary.: Background: Few studies exist on ERPs and patients with subcortical vascular cognitive impairment (SVCI). This latter is a quite homogeneous subtype of vascular dementia whose cognitive profile is quite different from that of Alzheimer disease (AD). Aims: The present study aims at comparing the ERPs profile both in patients with SVCI and in patients with AD. Subjects and methods: ERPs and psychometric tests were collected from 39 healthy elderly controls, 51 patients with SVCI and 43 patients with AD. Subjects mentally count high pitched target tones that were randomly intermixed with low pitched frequent tones. We measured ERPs latencies (N1, P2, N2 and P3), and interpeak latencies (N1-P3, N1-P2, N1-N2). Results: Grand averaged potentials in SVCI showed a significant increase of P3 latency. AD patients showed a prolongation of N1, P2, N2, P3 latencies. As far as interpeak latencies are concerned, SVCI patients showed a significant prolongation of N1-P3, AD patients had a significant increase of N1-N2, and N1-P3 intervals. When all patients were considered as a single group, correlation of neuropsychological tests scores showed a significant negative relationship between P300 latency and, respectively, Mini Mental Status Examination, auditive and visual span forward. In both groups, ERPs latency sensitivity, was low, whilst specificity values were quite high. Conclusions: Our finding suggest that these two dementing diseases have different electrophysiologic features that may be related to their specific underlying pathogenetic mechanism; in particular, we hypothesise that, differently from AD, P300 latency prolongation characterizes the early stage of SVCI. So, this ERPs approach could be helpful to detect early alterations of the attentional/working-memory functions in patients with subcortical ischaemic vascular disease. Springer-Verlag, 2006 Keywords: ERPs, vascular cognitive impairment, dementia nationallicence Muscoso E. G. Department of Senescent Urological and Neuro-urological Sciences, "Cannizzaro” Hospital, University of Catania, Catania, Italy aut Costanzo E. Department of Neurology, "Cannizzaro” Hospital, Catania, Italy aut Daniele O. Neurophysiological Unit, Institute of Neuropsychiatry, University of Palermo, Palermo, Italy aut Maugeri D. Department of Senescent Urological and Neuro-urological Sciences, "Cannizzaro” Hospital, University of Catania, Catania, Italy aut Natale E. Department of Neurology, Civil Hospital A.R.N.A.S., Palermo, Italy aut Caravaglios G. Department of Neurology, "Cannizzaro” Hospital, Catania, Italy aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1779-1786 0300-9564 113:11<1779 2006 113 702 https://doi.org/10.1007/s00702-006-0574-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0574-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muscoso E. G. Department of Senescent Urological and Neuro-urological Sciences, "Cannizzaro” Hospital, University of Catania, Catania, Italy aut NATIONALLICENCE 700 1- Costanzo E. Department of Neurology, "Cannizzaro” Hospital, Catania, Italy aut NATIONALLICENCE 700 1- Daniele O. Neurophysiological Unit, Institute of Neuropsychiatry, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Maugeri D. Department of Senescent Urological and Neuro-urological Sciences, "Cannizzaro” Hospital, University of Catania, Catania, Italy aut NATIONALLICENCE 700 1- Natale E. Department of Neurology, Civil Hospital A.R.N.A.S., Palermo, Italy aut NATIONALLICENCE 700 1- Caravaglios G. Department of Neurology, "Cannizzaro” Hospital, Catania, Italy aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1779-1786 0300-9564 113:11<1779 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer