caa a22 4500 467881804 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0551-1 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0551-1 Motor cortex inhibitory circuits in dementia with Lewy bodies and in Alzheimer's disease [Elektronische Daten] [R. Nardone, A. Bratti, F. Tezzon] Summary.: To determine whether a peculiar neurophysiological profile may contribute to characterize dementia with Lewy bodies (DLB) vs. Alzheimer disease (AD), we used transcranial magnetic stimulation to examine the excitability of two different inhibitory systems of the motor cortex, short latency intracortical inhibition (SICI) and short latency afferent inhibition (SAI) in 10 patients with DLB, in 13 patients with AD and in 15 healthy subjects. SICI and SAI were significantly reduced in AD patients, while both were not significantly different from the controls in DLB patients. The differential pattern of SICI and SAI exhibited by AD vs. DLB may have diagnostic significance in discriminating DLB from AD. Furthermore, this technique may help to clarify the pathophysiological entity of DLB; since SAI is a cortical phenomenon that depends on central cholinergic activity, our findings suggest that the mechanisms of cholinergic depletion in DLB may be different from that in AD, while normal SICI may reflect a less pronounced dysregulation of the intracortical GABAergic inhibitory circuitries in DLB. Springer-Verlag, 2006 Keywords: Dementia with Lewy bodies, Alzheimer's disease, transcranial magnetic stimulation, afferent inhibition, acethylcoline, muscarinic receptors nationallicence Nardone R. Department of Neurology, "F. Tappeiner” Hospital, Meran/o, Italy aut Bratti A. Department of Neurology, "F. Tappeiner” Hospital, Meran/o, Italy aut Tezzon F. Department of Neurology, "F. Tappeiner” Hospital, Meran/o, Italy aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1679-1684 0300-9564 113:11<1679 2006 113 702 https://doi.org/10.1007/s00702-006-0551-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0551-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nardone R. Department of Neurology, "F. Tappeiner” Hospital, Meran/o, Italy aut NATIONALLICENCE 700 1- Bratti A. Department of Neurology, "F. Tappeiner” Hospital, Meran/o, Italy aut NATIONALLICENCE 700 1- Tezzon F. Department of Neurology, "F. Tappeiner” Hospital, Meran/o, Italy aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1679-1684 0300-9564 113:11<1679 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer