caa a22 4500 467881847 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0592-5 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0592-5 Alois Alzheimer revisited: differences in origin of the disease carrying his name [Elektronische Daten] [K. Maurer, S. Hoyer] Summary.: Based on the means of his time, Alois Alzheimer supposed that the disease, later carrying his name, is a disease of older age, and that the pathomorphological structures he described are due to disturbances in brain metabolism. In this contribution, it is discussed which cellular metabolic abnormalities may be representative for age-related sporadic Alzheimer disease (SAD) the predominant form of SAD in contrast to the very rare hereditary early-onset form. In focus are disturbances in glucose/energy metabolism which involve the deficits in acetylcholine, cholesterol and UDP-N-acetylglucosamine beside ATP. Another leading abnormality is the defect in cell membrane composition. The interrelation between abnormal glucose/energy metabolism and membrane defect may be assumed to form the basis for the induction of both the perturbed metabolism of the amyloid precursor protein leading to increased formation of β-amyloid and hyperphosphorylation of tau-protein destroying cell structures. Alois Alzheimer may have been so prescient to assume most of this 100 years ago. Springer-Verlag, 2006 Keywords: Sporadic Alzheimer disease, history, brain, nutrition, energy metabolism, membranes nationallicence Maurer K. Clinic for Psychiatry, University of Frankfurt, Frankfurt/Main, Germany aut Hoyer S. Department of Pathology, University of Heidelberg, Heidelberg, Germany aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1645-1658 0300-9564 113:11<1645 2006 113 702 https://doi.org/10.1007/s00702-006-0592-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0592-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maurer K. Clinic for Psychiatry, University of Frankfurt, Frankfurt/Main, Germany aut NATIONALLICENCE 700 1- Hoyer S. Department of Pathology, University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1645-1658 0300-9564 113:11<1645 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer