caa a22 4500 467881855 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0537-z doi (NATIONALLICENCE)springer-10.1007/s00702-006-0537-z CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies [Elektronische Daten] [M. Bibl, B. Mollenhauer, H. Esselmann, P. Lewczuk, C. Trenkwalder, P. Brechlin, E. Rüther, J. Kornhuber, M. Otto, J. Wiltfang] Summary.: Differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) is often crucial. CSF Tau protein and Amyloid-beta (Aβ) peptides have shown diagnostic value for the diagnosis of AD, but discrimination from DLB was poor. Herein, we investigate CSF of 18 patients with probable AD, 25 with probable DLB and 14 non-demented disease controls (NDC) by Aβ-SDS-PAGE/immunoblot and commercially available ELISAs for Aβ1-42 and tau. CSF Aβ peptide patterns and tau exhibited disease specific alterations among AD and DLB. The ratio of Aβ1-42 to Aβ1-38 and Aβ1-42 to Aβ1-37, respectively, in combination with absolute tau, yielded a sensitivity and specificity of 100 and 92%, respectively. We conclude that CSF Aβ peptide patterns and tau levels reflect disease-specific pathophysiological pathways of these dementias as distinct neurochemical phenotypes. Combined evaluation of these biomarkers provides a reasonable accuracy for differential diagnosis of AD and DLB. Springer-Verlag, 2006 Keywords: Alzheimer's dementia, Lewy-body dementia, cerebrospinal fluid, amyloid-β peptides, tau protein, biomarker nationallicence Aβ peptides : amyloid-beta peptides nationallicence Aβ-SDS-PAGE/immunoblot : amyloid-beta-sodium-dodecyl-sulphate-polyacrylamide-gel-electrophoresis with western immunoblot nationallicence AD : Alzheimer's disease nationallicence ApoE ɛ4 : apolipoprotein E allele ɛ4 nationallicence APP : beta-amyloid precursor protein nationallicence bicine : N,N′-bis-[2-hydroxyethyl]glycine nationallicence CCD-camera : charge coupled device camera nationallicence CSF : cerebrospinal fluid nationallicence Ct-elongated : carboxyterminally elongated nationallicence Ct-truncated : carboxyterminally truncated nationallicence DLB : dementia with Lewy bodies nationallicence ECL : enhanced chemiluminescence nationallicence ELISA : Enzyme Linked Immunosorbent Assay nationallicence MMSE : Mini-Mental-Status Examination nationallicence NINCDS-ADRDA : National Institute Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association nationallicence ND : non-demented nationallicence PDD : Parkinson's disease dementia nationallicence PVDF : polyvinylidene difluoride nationallicence SDS : sodium dodecyl sulphate nationallicence Bibl M. Department of Psychiatry, University of Goettingen, Goettingen, Germany aut Mollenhauer B. Brigham and Women's Hospital, Center for Neurologic Diseases, Harvard Medical School, Boston, Massachusetts, USA aut Esselmann H. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut Lewczuk P. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut Trenkwalder C. University of Goettingen, Paracelsus-Elena Klinik, Kassel, Germany aut Brechlin P. Department of Psychiatry, University of Goettingen, Goettingen, Germany aut Rüther E. Department of Psychiatry, University of Goettingen, Goettingen, Germany aut Kornhuber J. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut Otto M. Department of Neurology, University of Ulm, Germany aut Wiltfang J. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1771-1778 0300-9564 113:11<1771 2006 113 702 https://doi.org/10.1007/s00702-006-0537-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0537-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bibl M. Department of Psychiatry, University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Mollenhauer B. Brigham and Women's Hospital, Center for Neurologic Diseases, Harvard Medical School, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Esselmann H. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Lewczuk P. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Trenkwalder C. University of Goettingen, Paracelsus-Elena Klinik, Kassel, Germany aut NATIONALLICENCE 700 1- Brechlin P. Department of Psychiatry, University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Rüther E. Department of Psychiatry, University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Kornhuber J. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Otto M. Department of Neurology, University of Ulm, Germany aut NATIONALLICENCE 700 1- Wiltfang J. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1771-1778 0300-9564 113:11<1771 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer