caa a22 4500 46788188X CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0517-3 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0517-3 Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain [Elektronische Daten] [S. Kanematsu, S. Ishii, A. Umino, T. Fujihira, A. Kashiwa, N. Yamamoto, A. Kurumaji, T. Nishikawa] Summary.: The continuous intra-cortical infusion of a glia toxin, fluorocitrate, at the concentration of 1 mM caused a decrease in the cortical extracellular contents of an intrinsic coagonist for the N-methyl-D-aspartate (NMDA) type glutamate receptor, D-serine, by peaking at 40 min by −25% but produced an increase in those of glycine and L-serine. The attenuated glial activity by fluorocitrate was verified by a marked reduction in the extracellular glutamine contents. The present findings suggest that a group of glial cells such as a population of the protoplasmic astrocytes could, at least in part, participate differently in the regulation of the extracellular release of D-serine and another NMDA coagonist glycine in the medial frontal cortex of the rat. Springer-Verlag, 2006 Keywords: D-Serine, extracellular contents, fluorocitrate, glia, in vivo microdialysis, medial frontal cortex nationallicence Kanematsu S. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Ishii S. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Umino A. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Fujihira T. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Kashiwa A. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Yamamoto N. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Kurumaji A. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Nishikawa T. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1717-1721 0300-9564 113:11<1717 2006 113 702 https://doi.org/10.1007/s00702-006-0517-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0517-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kanematsu S. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishii S. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Umino A. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujihira T. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Kashiwa A. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamamoto N. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Kurumaji A. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Nishikawa T. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1717-1721 0300-9564 113:11<1717 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer