caa a22 4500 467881898 CHVBK 20180406152722.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00702-006-0485-7 doi (NATIONALLICENCE)springer-10.1007/s00702-006-0485-7 Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease [Elektronische Daten] [H. Kessler, F.-G. Pajonk, P. Meisser, T. Schneider-Axmann, K.-H. Hoffmann, T. Supprian, W. Herrmann, R. Obeid, G. Multhaup, P. Falkai, T. A. Bayer] Summary.: Increasing evidence links Alzheimer's disease (AD) with misbalanced Cu homeostasis. Recently, we have shown that dietary Cu supplementation in a transgenic mouse model for AD increases bioavailable brain Cu levels, restores Cu, Zn-super oxide-1 activity, prevents premature death, and lowers Aβ levels. In the present report we investigated AD patients with normal levels of Aβ42, Tau and Phospho-Tau in the cerebrospinal fluid (CSF) in comparison with AD patients exhibiting aberrant levels in these CSF biomarkers. The influence of these cerebrospinal fluid (CSF) diagnostic markers with primary dependent variables blood Cu, Zn and ceruloplasmin (CB) and secondary with CSF profiles of Cu, Zn and neurotransmitters was determined. Multivariate tests revealed a significant effect of factor diagnostic group (no AD diagnosis in CSF or AD diagnosis in CSF) for variables plasma Cu and CB (F = 4.80; df = 2, 23; p = 0.018). Subsequent univariate tests revealed significantly reduced plasma Cu (−12.7%; F = 7.05; df = 1, 25; p = 0.014) and CB (−14.1%; F = 9.44; df = 1, 24; p = 0.005) levels in patients with aberrant CSF biomarker concentrations. Although only AD patients were included, the reduced plasma Cu and CB levels in patients with a CSF diagnosis of advanced AD supports previous observations that a mild Cu deficiency might contribute to AD progression. Springer-Verlag, 2006 Keywords: CSF, copper, Alzheimer's disease nationallicence Kessler H. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Pajonk F.-G Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Meisser P. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Schneider-Axmann T. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Hoffmann K.-H Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Supprian T. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Herrmann W. Department for Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg/Saar, Germany aut Obeid R. Department for Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg/Saar, Germany aut Multhaup G. Institute for Chemistry-Biochemistry, Free University of Berlin, Berlin, Germany aut Falkai P. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Bayer T. A. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1763-1769 0300-9564 113:11<1763 2006 113 702 https://doi.org/10.1007/s00702-006-0485-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-006-0485-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kessler H. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Pajonk F.-G Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Meisser P. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Schneider-Axmann T. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Hoffmann K.-H Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Supprian T. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Herrmann W. Department for Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Obeid R. Department for Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Multhaup G. Institute for Chemistry-Biochemistry, Free University of Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Falkai P. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Bayer T. A. Department of Psychiatry and Psychotherapy, Saarland University, Homburg/Saar, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer-Verlag 113/11(2006-11-01), 1763-1769 0300-9564 113:11<1763 2006 113 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer