caa a22 4500 46788322X CHVBK 20180406152726.0 cr unu---uuuuu 170328e20061201xx s 000 0 eng 10.1007/s00063-006-1125-6 doi (NATIONALLICENCE)springer-10.1007/s00063-006-1125-6 Value of Diabetes as an Independent Predictor of Death in Subjects with End-Stage Renal Disease [Elektronische Daten] [Michael Koch, Markus Hollenbeck, Rudolf Trapp, Wolfgang Kulas, Bernd Grabensee] Bedeutung des Diabetes als unabhängiger Prädiktor für den Tod bei Patienten mit terminaler Niereninsuffizienz Background and Purpose:: Diabetic subjects on hemodialysis have a poor survival. The authors performed a Kaplan-Meier survival analysis of diabetic versus nondiabetic subjects and investigated the value of diabetes as an independent predictor of death in these end-stage renal disease (ESRD) subjects. Patients and Methods:: From 1997 to 2003, 135 ESRD subjects (41 diabetics) were enrolled in a survival study beginning at the start of dialysis. Inclusion criterion was onset of dialysis at least 6 months before study entry. Exclusion criteria comprised age < 45 years, coronary artery disease (CAD), critical limb ischemia (CLI), or malignancies at ESRD onset up to 6 months after study entry. Subjects with clinical signs of vascular disease were followed up by coronary or peripheral angiographies. Results:: Baseline risk factors were similar between diabetic and nondiabetic subjects. The 5-year survival rate in nondiabetic subjects was 76.9% (95% confidence interval [CI] = 62-86%) versus 76.4% (95% CI = 53-89%) in diabetic patients (p = 0.402). Consistent with this finding, the Cox proportional hazards model revealed that diabetes does not significantly change the risk of death in ESRD subjects. De novo CAD developed in 35 and CLI in ten subjects, but both diseases were present more frequently in nonsurvivors (42% vs. 23%; p = 0.052) versus survivors (21% vs. 5%; p = 0.005). Conclusion:: Diabetes is not an independent predictor of death in the ESRD study group presented here. Prevention of CAD and CLI in diabetic subjects is most important to improve survival. Urban & Vogel München, 2006 End-stage renal disease nationallicence Diabetes nationallicence Predictor of death nationallicence Terminale Niereninsuffizienz nationallicence Diabetes nationallicence Prädiktor für Tod nationallicence Koch Michael Center of Nephrology, Mettmann, Germany aut Hollenbeck Markus Department of Nephrology, Heinrich Heine University, Düsseldorf, Germany aut Trapp Rudolf Center of Nephrology, Mettmann, Germany aut Kulas Wolfgang Center of Nephrology, Mettmann, Germany aut Grabensee Bernd Department of Nephrology, Heinrich Heine University, Düsseldorf, Germany aut Medizinische Klinik Urban & Vogel 101/12(2006-12-01), 933-937 0723-5003 101:12<933 2006 101 63 https://doi.org/10.1007/s00063-006-1125-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00063-006-1125-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koch Michael Center of Nephrology, Mettmann, Germany aut NATIONALLICENCE 700 1- Hollenbeck Markus Department of Nephrology, Heinrich Heine University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Trapp Rudolf Center of Nephrology, Mettmann, Germany aut NATIONALLICENCE 700 1- Kulas Wolfgang Center of Nephrology, Mettmann, Germany aut NATIONALLICENCE 700 1- Grabensee Bernd Department of Nephrology, Heinrich Heine University, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Medizinische Klinik Urban & Vogel 101/12(2006-12-01), 933-937 0723-5003 101:12<933 2006 101 63 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer