caa a22 4500 46789521X CHVBK 20180406152801.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s11103-006-9012-3 doi (NATIONALLICENCE)springer-10.1007/s11103-006-9012-3 Genome-wide investigation on the genetic variations of rice disease resistance genes [Elektronische Daten] [Sihai Yang, Zhumei Feng, Xiuyan Zhang, Ke Jiang, Xinqing Jin, Yueyu Hang, Jian-Qun Chen, Dacheng Tian] Exploitation of plant disease resistance (R) gene in breeding programs has been proven to be the most efficient strategy for coping with the threat of pathogens. An understanding of R-gene variation is the basis for this strategy. Here we report a genome-wide investigation on the variation of NBS-LRR-encoding genes, the common type of R genes, between two sequenced rice genomes, Oryza sativa L. var. Nipponbare and 93-11. We show that the allelic nucleotide diversity in 65.0% of 397 least-divergent pairs is not high (0.344% on average), while the remaining 35% display a greater diversity (5.4% on average). The majority of conserved R genes is single-copy and/or located as a singleton. The clustered, particularly the complex-clustered, R-genes contribute greatly to the rich genetic variation. Surprisingly only 11.2% of R-genes have remarkably high ratios of non-synonymous to synonymous rates, which is much less than the 17.4% observed between Arabidopsis genomes. Noticeable "artificially selective sweeping” could be detected in a large proportion of the conserved R-genes, a scenario described in the "arms race” co-evolutionary model. Based on our study, a variation pattern of R-genes is proposed and confirmed by the analysis of R-genes from other rice lines, indicating that the observed variation pattern may be common in all rice lines. Springer Science+Business Media B.V., 2006 Disease resistance genes nationallicence Genomic comparison nationallicence Rice nationallicence Variation nationallicence Yang Sihai State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Feng Zhumei State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Zhang Xiuyan State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Jiang Ke State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Jin Xinqing State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Hang Yueyu Institute of Botany, Jiangsu Province & Chinese Academy of Science, 210014, Nanjing, China aut Chen Jian-Qun State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Tian Dacheng State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut Plant Molecular Biology Kluwer Academic Publishers 62/1-2(2006-09-01), 181-193 0167-4412 62:1-2<181 2006 62 11103 https://doi.org/10.1007/s11103-006-9012-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11103-006-9012-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Sihai State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 700 1- Feng Zhumei State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 700 1- Zhang Xiuyan State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 700 1- Jiang Ke State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 700 1- Jin Xinqing State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 700 1- Hang Yueyu Institute of Botany, Jiangsu Province & Chinese Academy of Science, 210014, Nanjing, China aut NATIONALLICENCE 700 1- Chen Jian-Qun State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 700 1- Tian Dacheng State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, 210093, Nanjing, China aut NATIONALLICENCE 773 0- Plant Molecular Biology Kluwer Academic Publishers 62/1-2(2006-09-01), 181-193 0167-4412 62:1-2<181 2006 62 11103 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer