caa a22 4500 467905479 CHVBK 20180406152832.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s10735-006-9055-4 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9055-4 Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers [Elektronische Daten] [Yong Wang, Shizhong Wang, Yongyi Bao, Cheng Ni, Naifu Guan, Jianzhong Zhao, Leif Salford, Bengt Widegren, Xiaolong Fan] Adenoviral vector mediated gene delivery has been applied in clinical trials and mechanistic studies to explore new treatment approaches for lung cancers. The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly determines the permissiveness of lung cancer cells. CAR expression is also suggested to modulate tumor cell proliferation capacity. Here, we studied CAR expression in archival lung cancer specimens by using well-characterized CAR 72 antibodies. High levels of CAR expression were observed in most of the 32 cases of squamous cell carcinoma lung cancers and in all the five cases of small cell lung cancers investigated. In contrast, high levels of CAR expression were detected only in 6 of 22 adenocarcinoma lung cancers. The relative levels of CAR expression did not correlate with the pathologic grade in lung cancers, and was thus inconsistent with a role of modulating cancer cell proliferation. Of note, CAR expression was not detected in non-malignant alveolar cells. Our data suggest a preferred utility of Ad5 vector mediated gene delivery to squamous cell carcinoma lung cancers, small cell lung cancers, but not to the majority of adenocarcinoma lung cancers. Springer Science+Business Media, Inc., 2006 CAR nationallicence Recombinant adenoviral vector nationallicence Lung cancer nationallicence Wang Yong Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut Wang Shizhong Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut Bao Yongyi Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut Ni Cheng Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut Guan Naifu Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut Zhao Jianzhong Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut Salford Leif The Rausing laboratory, Lund University Hospital, Lund, Sweden aut Widegren Bengt The Rausing laboratory, Lund University Hospital, Lund, Sweden aut Fan Xiaolong The Rausing laboratory, Lund University Hospital, Lund, Sweden aut Journal of Molecular Histology Kluwer Academic Publishers 37/3-4(2006-05-01), 153-160 1567-2379 37:3-4<153 2006 37 10735 https://doi.org/10.1007/s10735-006-9055-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9055-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Yong Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut NATIONALLICENCE 700 1- Wang Shizhong Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut NATIONALLICENCE 700 1- Bao Yongyi Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut NATIONALLICENCE 700 1- Ni Cheng Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut NATIONALLICENCE 700 1- Guan Naifu Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut NATIONALLICENCE 700 1- Zhao Jianzhong Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China aut NATIONALLICENCE 700 1- Salford Leif The Rausing laboratory, Lund University Hospital, Lund, Sweden aut NATIONALLICENCE 700 1- Widegren Bengt The Rausing laboratory, Lund University Hospital, Lund, Sweden aut NATIONALLICENCE 700 1- Fan Xiaolong The Rausing laboratory, Lund University Hospital, Lund, Sweden aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/3-4(2006-05-01), 153-160 1567-2379 37:3-4<153 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer