caa a22 4500 467905509 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s10735-006-9048-3 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9048-3 Expression of cell cycle regulatory proteins in epithelial components of dental follicles [Elektronische Daten] [Mariza Matsumoto, Hugo Filho, Francine Jorge, Daisy Salvadori, Mariângela Marques, Daniel Ribeiro] Dental follicle is a component of tooth germs, which remain adjacent to the crown of unerupted or impacted teeth. Under the influence of pathologic changes, however, dental follicles that possess reduced epithelium can proliferate into stratified squamous epithelium as far as originate dental cysts. In order to clarify the role of apoptosis and cellular proliferation herein, expression of p53 and PCNA was examined in epithelial components of dental follicles associated with impacted third molars by means of immunohistochemistry. A total of 40 cases was included in this study being 22 cases with reduced epithelium and 18 cases with stratified epithelium. Expression of p53 expression was weak or not detected in dental follicles with reduced and stratified squamous epithelium. By contrast, PCNA positive cells were evidenced in basal and supra basal layers of the stratified squamous epithelium and in reduced epithelium of dental follicles, but without any significant statistically differences between them (P>0.05). In conclusion, these data suggest that dental follicles possess proliferative activity as depicted by PCNA-positive nuclei in some epithelial cells. However, the biological behavior of dental follicles during the late stage of dental eruptive process may not be associated with deregulation of death and/or cell proliferation. Springer Science+Business Media B.V., 2006 Dental follicles nationallicence Apoptosis nationallicence Cell proliferation nationallicence p53 nationallicence PCNA nationallicence Matsumoto Mariza Department of Dental Clinics, University of Sacred Heart, Bauru, SP, Brazil aut Filho Hugo Department of Dental Clinics, University of Sacred Heart, Bauru, SP, Brazil aut Jorge Francine Department of Dental Clinics, University of Sacred Heart, Bauru, SP, Brazil aut Salvadori Daisy Department of Pathology, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil aut Marques Mariângela Department of Pathology, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil aut Ribeiro Daniel Department of Pathology, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil aut Journal of Molecular Histology Kluwer Academic Publishers 37/3-4(2006-05-01), 127-131 1567-2379 37:3-4<127 2006 37 10735 https://doi.org/10.1007/s10735-006-9048-3 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9048-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsumoto Mariza Department of Dental Clinics, University of Sacred Heart, Bauru, SP, Brazil aut NATIONALLICENCE 700 1- Filho Hugo Department of Dental Clinics, University of Sacred Heart, Bauru, SP, Brazil aut NATIONALLICENCE 700 1- Jorge Francine Department of Dental Clinics, University of Sacred Heart, Bauru, SP, Brazil aut NATIONALLICENCE 700 1- Salvadori Daisy Department of Pathology, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil aut NATIONALLICENCE 700 1- Marques Mariângela Department of Pathology, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil aut NATIONALLICENCE 700 1- Ribeiro Daniel Department of Pathology, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/3-4(2006-05-01), 127-131 1567-2379 37:3-4<127 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer