caa a22 4500 467905541 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9032-y doi (NATIONALLICENCE)springer-10.1007/s10735-006-9032-y Importin KPNA2, NBS1, DNA Repair and Tumorigenesis [Elektronische Daten] [Shu-Chun Teng, Kou-Juey Wu, Shun-Fu Tseng, Chui-Wei Wong, Li Kao] During the past 20years, the MRE11-RAD50-NBS1 complex has become an increasingly important focus in basic and clinical cancer research. One main conceptual step forward was made with the discovery of NBS1 and the understanding of its critical pathophysiological role in Nijmegen breakage syndrome. Major efforts were carried out to define the role in DNA repair of this complex. Recently, basic research has continuously extended our understanding of the complexity of the NBS1 complex. MRE11-RAD50-NBS1 complex can no longer be viewed as having a single role in DNA damage repair since it also serves as a sensor and a mediator in cell cycle checkpoint signaling. Meanwhile, studies have challenged the concept that NBS1 only functions as a tumor suppressor in preserving genome integrity in the nucleus. It may also provide an oncogenic role in the cytoplasm which is associated with the PI3-kinase/AKT-activation pathway. Consistent with this aspect, a growing body of clinical evidence suggests that NBS1 contains a deleterious character that depends on its subcellular localization. This review focuses on recent experimental evidences demonstrating how NBS1 is translocated into the nucleus by an importin KPNA2 which mediates NBS1 subcellular localization and the functions of the NBS1 complex in tumorigenesis. Springer Science+Business Media B.V., 2006 Importin nationallicence KPNA2 nationallicence NBS1 nationallicence DNA repair nationallicence Cancer nationallicence Tumorigenesis nationallicence Teng Shu-Chun Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut Wu Kou-Juey Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan aut Tseng Shun-Fu Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut Wong Chui-Wei Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut Kao Li Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 293-299 1567-2379 37:5-7<293 2006 37 10735 https://doi.org/10.1007/s10735-006-9032-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9032-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Teng Shu-Chun Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wu Kou-Juey Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Tseng Shun-Fu Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wong Chui-Wei Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut NATIONALLICENCE 700 1- Kao Li Department of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, 10063, Taipei, Taiwan aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 293-299 1567-2379 37:5-7<293 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer