caa a22 4500 467905568 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9052-7 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9052-7 Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control [Elektronische Daten] [B. Shannan, M. Seifert, D. Boothman, W. Tilgen, J. Reichrath] The glycoprotein clusterin (CLU), has two known isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is pro-apoptotic, while a secretory form (sCLU) is pro-survival. Both forms are implicated in various cell functions, including DNA repair, cell cycle regulation, and apoptotic cell death. CLU expression has been associated with tumorigenesis and the progression of various malignancies. In response to DNA damage, cell survival can be enhanced by activation of DNA repair mechanisms, while simultaneously stimulating energy-expensive cell cycle checkpoints that delay the cell cycle progression to allow more time for DNA repair. This review summarizes our current understanding of the role of clusterin in DNA repair, apoptosis, and cell cycle control and the relevance. Springer Science+Business Media, Inc., 2006 Clusterin nationallicence DNA repair nationallicence Double strand break nationallicence Apoptosis nationallicence Cell cycle control nationallicence Shannan B. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut Seifert M. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut Boothman D. Department of Oncology, Laboratory of Molecular Stress Responses, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA aut Tilgen W. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut Reichrath J. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 183-188 1567-2379 37:5-7<183 2006 37 10735 https://doi.org/10.1007/s10735-006-9052-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9052-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shannan B. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Seifert M. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Boothman D. Department of Oncology, Laboratory of Molecular Stress Responses, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA aut NATIONALLICENCE 700 1- Tilgen W. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Reichrath J. Department of Dermatology, The Saarland University Hospital, Building 18, 66421, Homburg/Saar, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 183-188 1567-2379 37:5-7<183 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer