caa a22 4500 467905576 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9062-5 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9062-5 The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer [Elektronische Daten] [Markus Seifert, Jörg Reichrath] The cellular DNA mismatch repair (MMR) pathway, involving the DNA mismatch repair genes MLH1 and MSH2, detects and repairs DNA replication errors. Defects in MSH2 and MLH1 account for most cases of hereditary non-polyposis colorectal cancer as well as for sporadic colorectal tumors. Additionally, increased expression of MSH2 RNA and/or protein has been reported in various malignancies. Loss of DNA MMR in mammalian cells has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics. Due to other functions besides its role in DNA repair, that include regulation of cell proliferation and apoptosis, MSH2 has recently been shown to be of importance for pathogenesis and progression of cancer. This review summarizes our present understanding of the function of MSH2 for DNA repair, cell cycle control, and apoptosis and discusses its importance for pathogenesis, progression and therapy of cancer. Springer Science+Business Media, Inc., 2006 Mismatch repair nationallicence Carcinogenesis nationallicence Apoptosis nationallicence Cell cycle control nationallicence UV-B nationallicence Seifert Markus Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Str., 66421, Homburg, Germany aut Reichrath Jörg Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Str., 66421, Homburg, Germany aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 301-307 1567-2379 37:5-7<301 2006 37 10735 https://doi.org/10.1007/s10735-006-9062-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9062-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seifert Markus Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Str., 66421, Homburg, Germany aut NATIONALLICENCE 700 1- Reichrath Jörg Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Str., 66421, Homburg, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 301-307 1567-2379 37:5-7<301 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer