caa a22 4500 467905592 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9030-0 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9030-0 Role of SUMO/Ubc9 in DNA Damage Repair and Tumorigenesis [Elektronische Daten] [Stergios Moschos, Yin-Yuan Mo] DNA damage repair is an important cell function for genome integrity and its deregulation can lead to genomic instability and development of malignancies. Sumoylation is an increasingly important ubiquitin-like modification of proteins affecting protein stability, enzymatic activity, nucleocytoplasmic trafficking, and protein-protein interactions. In particular, several important DNA repair enzymes are subject to sumoylation, which appears to play a role in copping with DNA damage insults. Recent reports indicate that Ubc9, the single SUMO E2 enzyme catalyzing the conjugation of SUMO to target proteins, is overexpressed in certain tumors, such as lung adenocarcinoma, ovarian carcinoma and melanoma, suggestive of its clinic significance. This review summarizes the most important DNA damage repair pathways which are potentially affected by Ubc9/SUMO and their role in regulating the function of several proteins involved in the DNA damage repair machinery. Springer Science+Business Media B.V., 2006 Ubc9 nationallicence SUMO nationallicence Sumoylation nationallicence DNA repair nationallicence Moschos Stergios Department of Medicine, Division of Hematology-Oncology, Hillman Cancer Research Pavilion, University of Pittsburgh Medical Center, 5117 Centre Avenue, Suite 1.32e, 15213, Pittsburgh, PA, USA aut Mo Yin-Yuan Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, 801 N. Rutledge, PO Box 19626, 62794, Springfield, IL, USA aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 309-319 1567-2379 37:5-7<309 2006 37 10735 https://doi.org/10.1007/s10735-006-9030-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9030-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moschos Stergios Department of Medicine, Division of Hematology-Oncology, Hillman Cancer Research Pavilion, University of Pittsburgh Medical Center, 5117 Centre Avenue, Suite 1.32e, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Mo Yin-Yuan Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, 801 N. Rutledge, PO Box 19626, 62794, Springfield, IL, USA aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 309-319 1567-2379 37:5-7<309 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer