caa a22 4500 467905614 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9034-9 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9034-9 Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair [Elektronische Daten] [Matthew Canning, Stephanie Nay, Arely Peña, Daniel Yarosh] Calcineurin inhibitors are drugs used to suppress the immune system by blocking the nuclear localization of the NFAT transcription factor. Systemic use of these drugs is essential to organ transplantation, but comes at the cost of elevated rates of skin cancer. They have been used topically in atopic dermatitis and other skin diseases on the assumption that they avoid the cancer risk by localized use. The results here show that in skin cells and artificial models of human skin, calcineurin inhibitors block UV-induced nuclear localization of NFAT, and significantly reduce repair of cyclobutane pyrimidine dimers induced in DNA. In addition they inhibit apoptosis of UV-irradiated cells. The effect of blocking nuclear localization of NFAT and inhibiting DNA repair should be considered in judging the risk of topical use of calcineurin inhibitors. Springer Science+Business Media B.V., 2006 Calcineurin inhibitors nationallicence NFAT nationallicence DNA repair nationallicence UVB nationallicence Keratinocytes nationallicence TNF-α nationallicence Living skin equivalents nationallicence Canning Matthew AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut Nay Stephanie AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut Peña Arely AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut Yarosh Daniel AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 285-291 1567-2379 37:5-7<285 2006 37 10735 https://doi.org/10.1007/s10735-006-9034-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9034-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Canning Matthew AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut NATIONALLICENCE 700 1- Nay Stephanie AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut NATIONALLICENCE 700 1- Peña Arely AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut NATIONALLICENCE 700 1- Yarosh Daniel AGI Dermatics, 205 Buffalo Ave., 11520, Freeport, NY, USA aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 285-291 1567-2379 37:5-7<285 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer