caa a22 4500 467905649 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9043-8 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9043-8 New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors [Elektronische Daten] [Melissa Bentle, Erik Bey, Ying Dong, Kathryn Reinicke, David Boothman] Defective or abortive repair of DNA lesions has been associated with carcinogenesis. Therefore it is imperative for a cell to accurately repair its DNA after damage if it is to return to a normal cellular phenotype. In certain circumstances, if DNA damage cannot be repaired completely and with high fidelity, it is more advantageous for an organism to have some of its more severely damaged cells die rather than survive as neoplastic transformants. A number of DNA repair inhibitors have the potential to act as anticarcinogenic compounds. These drugs are capable of modulating DNA repair, thus promoting cell death rather than repair of potentially carcinogenic DNA damage mediated by error-prone DNA repair processes. In theory, exposure to a DNA repair inhibitor during, or immediately after, carcinogenic exposure should decrease or prevent tumorigenesis. However, the ability of DNA repair inhibitors to prevent cancer development is difficult to interpret depending upon the system used and the type of genotoxic stress. Inhibitors may act on multiple aspects of DNA repair as well as the cellular signaling pathways activated in response to the initial damage. In this review, we summarize basic DNA repair mechanisms and explore the effects of a number of DNA repair inhibitors that not only potentiate DNA-damaging agents but also decrease carcinogenicity. In particular, we focus on a novel anti-tumor agent, β-lapachone, and its potential to block transformation by modulating poly(ADP-ribose) polymerase-1. Springer Science+Business Media B.V., 2006 DNA repair inhibitors nationallicence Carcinogenesis nationallicence β-Lapachone nationallicence DNA repair nationallicence NQO1 nationallicence Poly(ADP-ribose) polymerase-1 nationallicence DNA damage nationallicence Cancer therapy nationallicence Cancer prevention nationallicence Bentle Melissa Department of Pharmacology, Case Western Reserve University, 44106, Cleveland, OH, USA aut Bey Erik Department of Pharmacology, Laboratory of Molecular Stress Responses, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y-4 RM 206C, 75390, Dallas, TX, USA aut Dong Ying Department of Pharmacology, Laboratory of Molecular Stress Responses, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y-4 RM 206C, 75390, Dallas, TX, USA aut Reinicke Kathryn Department of Biochemistry, Case Western Reserve University, 44106, Cleveland, OH, USA aut Boothman David Department of Pharmacology, Laboratory of Molecular Stress Responses, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y-4 RM 206C, 75390, Dallas, TX, USA aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 203-218 1567-2379 37:5-7<203 2006 37 10735 https://doi.org/10.1007/s10735-006-9043-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9043-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bentle Melissa Department of Pharmacology, Case Western Reserve University, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Bey Erik Department of Pharmacology, Laboratory of Molecular Stress Responses, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y-4 RM 206C, 75390, Dallas, TX, USA aut NATIONALLICENCE 700 1- Dong Ying Department of Pharmacology, Laboratory of Molecular Stress Responses, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y-4 RM 206C, 75390, Dallas, TX, USA aut NATIONALLICENCE 700 1- Reinicke Kathryn Department of Biochemistry, Case Western Reserve University, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Boothman David Department of Pharmacology, Laboratory of Molecular Stress Responses, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y-4 RM 206C, 75390, Dallas, TX, USA aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 203-218 1567-2379 37:5-7<203 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer