caa a22 4500 467905657 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s10735-006-9039-4 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9039-4 DNA Damage Checkpoints and Cancer [Elektronische Daten] [Midori Shimada, Makoto Nakanishi] DNA damage checkpoint is one of the surveillance systems to maintain genomic integrity. Checkpoint systems sense the DNA damage and execute cell cycle arrest through inhibiting the activity of cell cycle regulators. This pathway is essential for the maintenance of genome stability and prevention of tumor development. Recent studies have showed that the cellular responses towards DNA damage, such as cell cycle arrest, DNA repair, chromatin remodeling, and apoptosis are well coordinated. Here we describe the molecular mechanisms of checkpoint activation in response to DNA damage and the correlation between checkpoint gene mutation and genomic instability. Springer Science+Business Media B.V., 2006 Cell cycle nationallicence DNA damage nationallicence Checkpoint nationallicence Cancer nationallicence Shimada Midori Department of Biochemistry and Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Mizuho-cho, 467-8601, Nagoya, Japan aut Nakanishi Makoto Department of Biochemistry and Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Mizuho-cho, 467-8601, Nagoya, Japan aut Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 253-260 1567-2379 37:5-7<253 2006 37 10735 https://doi.org/10.1007/s10735-006-9039-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9039-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shimada Midori Department of Biochemistry and Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Mizuho-cho, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Nakanishi Makoto Department of Biochemistry and Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Mizuho-cho, 467-8601, Nagoya, Japan aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/5-7(2006-09-01), 253-260 1567-2379 37:5-7<253 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer