caa a22 4500 467905746 CHVBK 20180406152833.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s10735-006-9059-0 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9059-0 High expression of APOBEC3G in patients infected with hepatitis C virus [Elektronische Daten] [Yoshihiro Komohara, Hirohisa Yano, Shigeki Shichijo, Kunitada Shimotohno, Kyogo Itoh, Akira Yamada] APOBEC3G (an apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G; also known as CEM15), a member of the APOBEC family, which possesses cytidine deaminase activity that causes C/G to T/A transition mutations in virus genomes such as human immunodeficiency virus 1 and hepatitis B virus, is reported to play an important role in host-defense mechanisms. However, APOBEC3G expression in patients infected with chronic hepatitis C virus (HCV), of which there are currently more than 170 million worldwide, has not yet been well studied. We investigated this issue herein, and demonstrated an increased expression of APOBEC3G in both hepatocytes and lymphocytes of chronic hepatitis patients infected with HCV. Transfection of the NS5A gene, but not any other non-structural protein genes of HCV tested, to the hepatocellular carcinoma cell line enhanced APOBEC3G expression. Incubation of the cells with interferon also resulted in the augmentation. These results may provide new insight into the pathogenesis of chronic HCV infection. Springer Science+Business Media, Inc., 2006 APOBEC3G nationallicence HCV nationallicence Hepatocytes nationallicence NS5A nationallicence Interferon nationallicence Komohara Yoshihiro Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut Yano Hirohisa Department of Pathology, Kurume University School of Medicine, Kurume, Japan aut Shichijo Shigeki Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut Shimotohno Kunitada Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto, Japan aut Itoh Kyogo Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut Yamada Akira Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut Journal of Molecular Histology Kluwer Academic Publishers 37/8-9(2006-11-01), 327-332 1567-2379 37:8-9<327 2006 37 10735 https://doi.org/10.1007/s10735-006-9059-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9059-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Komohara Yoshihiro Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Yano Hirohisa Department of Pathology, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Shichijo Shigeki Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Shimotohno Kunitada Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Itoh Kyogo Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Yamada Akira Department of Immunology, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/8-9(2006-11-01), 327-332 1567-2379 37:8-9<327 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer