caa a22 4500 467905800 CHVBK 20180406152834.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s10735-006-9027-8 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9027-8 Co-expression of interleukin-6 and human growth hormone in apparently normal prostate biopsies that ultimately progress to prostate cancer using low pH, high temperature antigen retrieval [Elektronische Daten] [M. Slater, C. R. Murphy] Prostate cancer is the most common cancer in American men and the second leading cause of cancer deaths in this group. Both growth hormone (GH) and the inflammatory cytokine interleukin 6 (IL-6) have been implicated in prostate cancer progression. Studies in other systems have shown that an increase in GH results in an increase in IL-6 also. The current study demonstrated a parallel spatial and temporal expression of GH and IL-6 in cells in prostate cancer glandular acina cells. This study cannot determine if this expression is coincidental or causative, but it seems likely that the increase in GH could induce the expression of IL-6, since this is the case in other tissues. Optimal labelling for IL-6 in our study was achieved with low pH, high temperature antigen retrieval. Springer Science+Business Media B.V., 2006 Prostate nationallicence Cancer nationallicence Immunolabeling nationallicence IL-6 nationallicence GH nationallicence Slater M. School of Medical Sciences, Department of Anatomy and Histology F13, The University of Sydney, 2006, Sydney, NSW, Australia aut Murphy C. R. School of Medical Sciences, Department of Anatomy and Histology F13, The University of Sydney, 2006, Sydney, NSW, Australia aut Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 37-41 1567-2379 37:1-2<37 2006 37 10735 https://doi.org/10.1007/s10735-006-9027-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9027-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Slater M. School of Medical Sciences, Department of Anatomy and Histology F13, The University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Murphy C. R. School of Medical Sciences, Department of Anatomy and Histology F13, The University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 37-41 1567-2379 37:1-2<37 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer