caa a22 4500 467905819 CHVBK 20180406152834.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s10735-006-9020-2 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9020-2 The Effects of Triiodothyronine on Rat Testis: A Morphometric and Immunohistochemical Study [Elektronische Daten] [Jale Öner, Hakan Öner, Neriman Çolakoğlu, Aysel Kükner, Enver Ozan] The aim of present study was to investigate the effects of 3,3′,5-triiodothyronine (T3) on rat testis both morphometrically and immunohistochemically with determining of insulin-like growth factor I (IGF-I) expression. Adult male Wistar-albino rats used in the study were divided into two groups; control and T3-treated groups. After T3 treatment there was observed to be a decrease in testicular weights, diameters of seminiferous tubules and the number of sertoli cells, and an increase in the number of leydig cells (P<0.05). Some of the seminiferous tubule lumens of T3 administrated rats had cellular debris. IGF-I was localized in sertoli cells, late spermatids and leydig cells of all groups. IGF-I immunoreactivity in T3 treated rats was higher than in controls in all stages of the cycle of rat seminiferous epithelium, but the staining intensity of leydig cells were similar in both groups. In conclusion, the present results suggest that T3 may modulate the testicular function by affecting IGF-I activity at the gonadal level. Springer Science+Business Media B.V., 2006 IGF-I nationallicence T3 nationallicence Testis nationallicence Öner Jale Department of Histology and Embryology, Faculty of Veterinary Medicine, Akdeniz University, 15100, Burdur, Turkey aut Öner Hakan Department of Histology and Embryology, Faculty of Veterinary Medicine, Akdeniz University, 15100, Burdur, Turkey aut Çolakoğlu Neriman Department of Histology and Embryology, Faculty of Medicine, Firat University, 23100, Elazığ, Turkey aut Kükner Aysel Department of Histology and Embryology, Medical Faculty of Izzet Baysal, Abant Izzet Baysal University, 14300, Bolu, Turkey aut Ozan Enver Department of Histology and Embryology, Faculty of Medicine, Firat University, 23100, Elazığ, Turkey aut Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 9-14 1567-2379 37:1-2<9 2006 37 10735 https://doi.org/10.1007/s10735-006-9020-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9020-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Öner Jale Department of Histology and Embryology, Faculty of Veterinary Medicine, Akdeniz University, 15100, Burdur, Turkey aut NATIONALLICENCE 700 1- Öner Hakan Department of Histology and Embryology, Faculty of Veterinary Medicine, Akdeniz University, 15100, Burdur, Turkey aut NATIONALLICENCE 700 1- Çolakoğlu Neriman Department of Histology and Embryology, Faculty of Medicine, Firat University, 23100, Elazığ, Turkey aut NATIONALLICENCE 700 1- Kükner Aysel Department of Histology and Embryology, Medical Faculty of Izzet Baysal, Abant Izzet Baysal University, 14300, Bolu, Turkey aut NATIONALLICENCE 700 1- Ozan Enver Department of Histology and Embryology, Faculty of Medicine, Firat University, 23100, Elazığ, Turkey aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 9-14 1567-2379 37:1-2<9 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer