caa a22 4500 467905843 CHVBK 20180406152834.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s10735-006-9035-8 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9035-8 Distribution of GDNF family receptor α3 and RET in rat and human non-neural tissues [Elektronische Daten] [Chunhua Yang, David Hutto, Dinah Sah] The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRα3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons. However, the presence and potential role of this artemin-responsive pathway in non-neural tissues has not been fully explored to-date. To study the distribution of GFRα3 and RET in adult rat and human non-neural tissues, we carried out a comprehensive immunohistochemical study. We stained major organs from the digestive, urinary, reproductive, immune, respiratory and endocrine systems, and from other systems (cardiovascular, skeletal muscle), as well as regions of the nervous system for comparison. In both rat and human, the majority of non-neural cells did not exhibit detectable GFRα3-like immunoreactivity. In the rat, GFRα3- and RET-like staining were found in the same non-neural cell type only in kidney. In the human digestive and reproductive systems, a subset of epithelial cells exhibited GFRα3- and RET-like staining, suggesting co-localization. In other tissues, sub-populations of cells expressed either GFRα3- or RET-like immunoreactivity. The functional consequences of GFRα3 expression in non-neural cells remain to be determined. Springer Science+Business Media B.V., 2006 Yang Chunhua BiogenIdec, Inc., 14 Cambridge Center, 02142, Cambridge, MA, USA aut Hutto David BiogenIdec, Inc., 14 Cambridge Center, 02142, Cambridge, MA, USA aut Sah Dinah Alnylam Pharmaceuticals, Inc., 300 Third Street, 02142, Cambridge, MA, USA aut Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 69-77 1567-2379 37:1-2<69 2006 37 10735 https://doi.org/10.1007/s10735-006-9035-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9035-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Chunhua BiogenIdec, Inc., 14 Cambridge Center, 02142, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Hutto David BiogenIdec, Inc., 14 Cambridge Center, 02142, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Sah Dinah Alnylam Pharmaceuticals, Inc., 300 Third Street, 02142, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 69-77 1567-2379 37:1-2<69 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer