caa a22 4500 46790586X CHVBK 20180406152834.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s10735-006-9029-6 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9029-6 Expression of Inhibin/activin Subunits alpha (- α ), beta A (- β A) and beta B (- β B) in Placental Tissue of Normal and Intrauterine Growth Restricted (IUGR) Pregnancies [Elektronische Daten] [I. Mylonas, B. Schiessl, U. Jeschke, J. Vogl, A. Makrigiannakis, C. Kuhn, S. Kunze, S. Schulze, F. Kainer, K. Friese] During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (β A or β B). Aims of the present study were the determination of the frequency and tissue distribution patterns of the inhibin/activin subunits in human placental tissue of normal pregnancies and pregnancies complicated with fetal growth restriction (IUGR). Slides of paraffin embedded placental tissue were obtained after delivery from patients diagnosed with IUGR (n = 6) and normal term placentas (n = 8). Tissue samples were fixed and incubated with monoclonal antibodies inhibin/activin-subunits -α, -β A, -β B. Intensity of immunohistochemical reaction on the slides was analysed using a semi-quantitative score and statistical analysis was performed (P<0.05). A significant lower expression of the inhibin-α subunit in IUGR extravillous trophoblast compared to normal pregnancies was observed, while the inhibin-α immunostaining was significantly upregulated in syncytiotrophoblast. Additionally, a significant down-regulation of inhibin-β B subunit in extravillous trophoblast cells in IUGR syncytiotrophoblast cells was demonstrated. A co-localisation of inhibin-α and the β-subunits was also observed, suggesting a production and secretion of intact inhibin A and inhibin B. Although the precise role of these inhibin/activin subunits in human placenta and IUGR pregnancies is still unclear, they could be involved in autocrine/paracrine signalling, contributing to several aspects like angiogenesis and tissue remodelling. Springer Science+Business Media B.V., 2006 Inhibin/activin subunits nationallicence Inhibin- α nationallicence Inhibin- β A nationallicence Inhibin- β B nationallicence Intrauterine growthrestriction (IUGR) nationallicence Extravillous trophoblast nationallicence Syncytiotrophoblast nationallicence Mylonas I. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Schiessl B. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Jeschke U. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Vogl J. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Makrigiannakis A. Department of Obstetrics and Gynecology, University of Crete, Crete, Heraklion, Greece aut Kuhn C. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Kunze S. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Schulze S. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Kainer F. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Friese K. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 43-52 1567-2379 37:1-2<43 2006 37 10735 https://doi.org/10.1007/s10735-006-9029-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9029-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mylonas I. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Schiessl B. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Jeschke U. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Vogl J. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Makrigiannakis A. Department of Obstetrics and Gynecology, University of Crete, Crete, Heraklion, Greece aut NATIONALLICENCE 700 1- Kuhn C. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Kunze S. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Schulze S. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Kainer F. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Friese K. 1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 43-52 1567-2379 37:1-2<43 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 462361640 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer