caa a22 4500 467905878 CHVBK 20180406152834.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s10735-006-9019-8 doi (NATIONALLICENCE)springer-10.1007/s10735-006-9019-8 Expression of Bcl-2 and Bax protein in normal pineal gland in children and young adult [Elektronische Daten] [Wiesław Marcol, Katarzyna Kotulska, Magdalena Larysz-Brysz, Izabela Malinowska-Kołodziej, Marek Mandera, Joanna Lewin-Kowalik] Summary: The Bcl family contains both pro and antiapoptotic proteins participating in the regulation of neuronal cell death in several pathological conditions. However, very little is known about physiological profiles of Bcl-2/Bax expression in normal brain. In this study, we examined expression profile of Bcl-2 and Bax proteins in normal pineal gland in children. The material for analysis was obtained by biopsy of pineal parenchyma during surgery of pineal cysts. All specimens were labeled immunohistochemically and analyzed by means of confocal laser scanning microscope. We found only few Bcl-2 expressing (0.7%) and no Bax-immunopositive (0.0%) pinealocytes. Bcl-2-positive cells were mature neurons, neither young ones nor glia. Springer Science+Business Media, Inc., 2006 Marcol Wiesław Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut Kotulska Katarzyna Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut Larysz-Brysz Magdalena Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut Malinowska-Kołodziej Izabela Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut Mandera Marek Division of Pediatric Neurosurgery, Department of Pediatric Surgery, Medical University of Silesia, Katowice, Poland aut Lewin-Kowalik Joanna Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 5-7 1567-2379 37:1-2<5 2006 37 10735 https://doi.org/10.1007/s10735-006-9019-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10735-006-9019-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marcol Wiesław Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut NATIONALLICENCE 700 1- Kotulska Katarzyna Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut NATIONALLICENCE 700 1- Larysz-Brysz Magdalena Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut NATIONALLICENCE 700 1- Malinowska-Kołodziej Izabela Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut NATIONALLICENCE 700 1- Mandera Marek Division of Pediatric Neurosurgery, Department of Pediatric Surgery, Medical University of Silesia, Katowice, Poland aut NATIONALLICENCE 700 1- Lewin-Kowalik Joanna Department of Physiology, Medical University of Silesia, 18 Medyków, 40-752, Katowice, Poland aut NATIONALLICENCE 773 0- Journal of Molecular Histology Kluwer Academic Publishers 37/1-2(2006-01-01), 5-7 1567-2379 37:1-2<5 2006 37 10735 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer