caa a22 4500 467906750 CHVBK 20180406152836.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00251-005-0064-3 doi (NATIONALLICENCE)springer-10.1007/s00251-005-0064-3 Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish [Elektronische Daten] [Patoula Panagos, Kimberly Dobrinski, Xianghong Chen, Amanda Grant, David Traver, Julie Djeu, Sheng Wei, Jeffrey Yoder] The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages. Springer-Verlag, 2006 C-type lectin nationallicence ITIM nationallicence Natural killer cells nationallicence Signaling motifs nationallicence Panagos Patoula Department of Biology, University of South Florida, 4202 East Fowler Avenue, 33620, Tampa, FL, USA aut Dobrinski Kimberly Department of Biology, University of South Florida, 4202 East Fowler Avenue, 33620, Tampa, FL, USA aut Chen Xianghong Immunology Program, H. Lee Moffitt Cancer and Research Institute, 12902 Magnolia Avenue, 33612, Tampa, FL, USA aut Grant Amanda Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, NC, USA aut Traver David Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA aut Djeu Julie Immunology Program, H. Lee Moffitt Cancer and Research Institute, 12902 Magnolia Avenue, 33612, Tampa, FL, USA aut Wei Sheng Immunology Program, H. Lee Moffitt Cancer and Research Institute, 12902 Magnolia Avenue, 33612, Tampa, FL, USA aut Yoder Jeffrey Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, NC, USA aut Immunogenetics Springer-Verlag 58/1(2006-02-01), 31-40 0093-7711 58:1<31 2006 58 251 https://doi.org/10.1007/s00251-005-0064-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-005-0064-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Panagos Patoula Department of Biology, University of South Florida, 4202 East Fowler Avenue, 33620, Tampa, FL, USA aut NATIONALLICENCE 700 1- Dobrinski Kimberly Department of Biology, University of South Florida, 4202 East Fowler Avenue, 33620, Tampa, FL, USA aut NATIONALLICENCE 700 1- Chen Xianghong Immunology Program, H. Lee Moffitt Cancer and Research Institute, 12902 Magnolia Avenue, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Grant Amanda Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, NC, USA aut NATIONALLICENCE 700 1- Traver David Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Djeu Julie Immunology Program, H. Lee Moffitt Cancer and Research Institute, 12902 Magnolia Avenue, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Wei Sheng Immunology Program, H. Lee Moffitt Cancer and Research Institute, 12902 Magnolia Avenue, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Yoder Jeffrey Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, NC, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/1(2006-02-01), 31-40 0093-7711 58:1<31 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer