caa a22 4500 467906785 CHVBK 20180406152836.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00251-005-0077-y doi (NATIONALLICENCE)springer-10.1007/s00251-005-0077-y The pattern of clinical breast cancer metastasis correlates with a single nucleotide polymorphism in the C1qA component of complement [Elektronische Daten] [Emilian Racila, Doina Racila, Justine Ritchie, Christiana Taylor, Christopher Dahle, George Weiner] Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] was performed in 63 breast cancer subjects with localized tumor and compared with that in 38 breast cancer subjects with metastasis. Established risk factors for clinical outcome were considered and evaluated in multivariable analysis. Breast cancer subjects with heterozygous or homozygous C1qA[276G] genotype had a higher rate of metastasis than subjects with the homozygous C1qA[276A] genotype [hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.1-4.1]. This association was stronger when only metastatic sites associated with hematogenous spread, i.e., to the bone, liver, and brain, were considered (HR 3.5, 95% CI 1.4-5.6) and remained statistically significant after adjustment for the number of positive lymph nodes, estrogen receptor status, and progesterone receptor status. There was no statistical difference in the C1qA[276A/G] allelic distribution between all subjects with breast cancer and controls. These results suggest there could be an association of a single nucleotide polymorphism at position 276 of the C1qA component of complement with breast cancer metastasis to sites linked to hematogenous spread of disease. The C1qA polymorphism associated with decreased distant metastasis has also been correlated with an increased incidence of subcutaneous systemic lupus and C1q deficiencies, suggesting that an altered immune response may play a role in the observed association. Springer-Verlag, 2006 Complement nationallicence Single nucleotide polymorphism (SNP) nationallicence Breast cancer nationallicence Metastasis nationallicence Racila Emilian Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut Racila Doina Department of Internal Medicine, University of Iowa, 52242, Iowa, IA, USA aut Ritchie Justine Department of Biostatistics, University of Iowa, 52242, Iowa City, IA, USA aut Taylor Christiana Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut Dahle Christopher Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut Weiner George Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut Immunogenetics Springer-Verlag 58/1(2006-02-01), 1-8 0093-7711 58:1<1 2006 58 251 https://doi.org/10.1007/s00251-005-0077-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-005-0077-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Racila Emilian Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut NATIONALLICENCE 700 1- Racila Doina Department of Internal Medicine, University of Iowa, 52242, Iowa, IA, USA aut NATIONALLICENCE 700 1- Ritchie Justine Department of Biostatistics, University of Iowa, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Taylor Christiana Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut NATIONALLICENCE 700 1- Dahle Christopher Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut NATIONALLICENCE 700 1- Weiner George Holden Comprehensive Cancer Center at the University of Iowa, 5216MERF, University of Iowa, 52242, Iowa, IA, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/1(2006-02-01), 1-8 0093-7711 58:1<1 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer