caa a22 4500 467906793 CHVBK 20180406152836.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00251-005-0079-9 doi (NATIONALLICENCE)springer-10.1007/s00251-005-0079-9 Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats [Elektronische Daten] [Tohru Suzuki, Akira Ishih, Hideto Kino, Francis Muregi, Shuji Takabayashi, Tetsu Nishikawa, Hisayoshi Takagi, Mamoru Terada] The differences in host response among strains of rats to intestinal nematode parasite Trichinella spiralis infection could provide a powerful benefit for further elucidation of molecular interactions between the host and the parasite. Using several strains of rats, we previously observed that DA strain is a strong responder and F344 strain is a weak responder with respect to expulsion of the adult worm. To identify the host resistance loci, quantitative trait loci (QTLs) analysis in F2 population from crosses between DA and F344 strains was performed. One significant QTL (designated as Tspe) was mapped to the middle region of chromosome 9. In addition, the effect of DA allele at Tspe locus could act recessively and lead to the rejection of more adult worms from the gut. The results from the present study provide more insights on host-parasite interactions, which may be useful in facilitating the development of novel approaches for treatment and control of intestinal parasites in human and domestic livestock. Springer-Verlag, 2006 Trichinella spiralis nationallicence Intestinal nematode nationallicence Quantitative trait loci mapping nationallicence Host resistance nationallicence Rat nationallicence Suzuki Tohru Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Ishih Akira Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Kino Hideto Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Muregi Francis Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Takabayashi Shuji Institute for Experimental Animals, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Nishikawa Tetsu Institute for Experimental Animals, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Takagi Hisayoshi Japan SLC, Inc., 3-5-1 Aoihigashi, 433-8114, Hamamatsu, Japan aut Terada Mamoru Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut Immunogenetics Springer-Verlag 58/1(2006-02-01), 26-30 0093-7711 58:1<26 2006 58 251 https://doi.org/10.1007/s00251-005-0079-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-005-0079-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Tohru Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Ishih Akira Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Kino Hideto Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Muregi Francis Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Takabayashi Shuji Institute for Experimental Animals, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Nishikawa Tetsu Institute for Experimental Animals, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Takagi Hisayoshi Japan SLC, Inc., 3-5-1 Aoihigashi, 433-8114, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Terada Mamoru Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/1(2006-02-01), 26-30 0093-7711 58:1<26 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer