caa a22 4500 467906866 CHVBK 20180406152836.0 cr unu---uuuuu 170328e20060901xx s 000 0 eng 10.1007/s00251-006-0134-1 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0134-1 A novel family of diversified immunoregulatory receptors in teleosts is homologous to both mammalian Fc receptors and molecules encoded within the leukocyte receptor complex [Elektronische Daten] [James Stafford, Eva Bengtén, Louis Du Pasquier, Robin McIntosh, Sylvie Quiniou, L. Clem, Norman Miller, Melanie Wilson] Three novel and closely related leukocyte immune-type receptors (IpLITR) have been identified in channel catfish (Ictalurus punctatus). These receptors belong to a large polymorphic and polygenic subset of the Ig superfamily with members located on at least three independently segregating loci. Like mammalian and avian innate immune regulatory receptors, IpLITRs have both putative inhibitory and stimulatory forms, with multiple types coexpressed in various lymphoid tissues and clonal leukocyte cell lines. IpLITRs have an unusual and novel relationship to mammalian and avian innate immune receptors: the membrane distal Ig domains of an individual IpLITR are related to fragment crystallizable receptors (FcRs) and FcR-like proteins, whereas the membrane proximal Ig domains are related to several leukocyte receptor complex encoded receptors. This unique composition of Ig domains within individual receptors supports the hypothesis that functionally and genomically distinct immune receptor families found in tetrapods may have evolved from such ancestral genes by duplication and recombination events. Furthermore, the discovery of a large heterogeneous family of immunoregulatory receptors in teleosts, reminiscent of amphibian, avian, and mammalian Ig-like receptors, suggests that complex innate immune receptor networks have been conserved during vertebrate evolution. Springer-Verlag, 2006 Evolution nationallicence Molecular immunology nationallicence Inhibitory receptors nationallicence Innate immunity nationallicence Teleosts nationallicence Stafford James Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut Bengtén Eva Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut Du Pasquier Louis Institute of Zoology, University of Basel, Basel, Switzerland aut McIntosh Robin Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut Quiniou Sylvie USDA-ARS/CGRU, 141 Experimental Station Road, 38701, Stoneville, MS, USA aut Clem L. Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut Miller Norman Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut Wilson Melanie Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut Immunogenetics Springer-Verlag 58/9(2006-09-01), 758-773 0093-7711 58:9<758 2006 58 251 https://doi.org/10.1007/s00251-006-0134-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0134-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stafford James Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut NATIONALLICENCE 700 1- Bengtén Eva Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut NATIONALLICENCE 700 1- Du Pasquier Louis Institute of Zoology, University of Basel, Basel, Switzerland aut NATIONALLICENCE 700 1- McIntosh Robin Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut NATIONALLICENCE 700 1- Quiniou Sylvie USDA-ARS/CGRU, 141 Experimental Station Road, 38701, Stoneville, MS, USA aut NATIONALLICENCE 700 1- Clem L. Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut NATIONALLICENCE 700 1- Miller Norman Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut NATIONALLICENCE 700 1- Wilson Melanie Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/9(2006-09-01), 758-773 0093-7711 58:9<758 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer