caa a22 4500 467906890 CHVBK 20180406152836.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00251-006-0124-3 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0124-3 Diversity of killer cell immunoglobulin-like receptor genes in Pacific Islands populations [Elektronische Daten] [Marija Velickovic, Zlatibor Velickovic, Heather Dunckley] Killer immunoglobulin-like receptors (KIRs) regulate the activity of NK and T cells through interaction with specific HLA class I molecules on target cells. To date, 16 KIR genes and pseudogenes have been identified. Diversity in KIR gene content and KIR allelic and haplotype polymorphism has been observed between different ethnic groups. Here, we present data on the KIR gene distribution in Pacific Islands populations. Sixteen KIR genes were observed in Pacific Islands populations from the Cook Islands, Samoa, Tokelau, and Tonga. The majority of KIR genes were present at similar frequencies between the four populations with KIR2DL4, KIR3DL2, and KIR3DP1 genes observed in all individuals. Commonly observed KIR genes in Pacific Islands populations (pooled frequencies) were KIR2DL1 (0.77), KIR2DL3 (0.77), KIR3DL1 (0.65), KIR3DL3 (0.93), KIR2DS4/1D (0.78), and KIR2DP1 (0.82), compared to the less-frequently observed KIR2DL2 (0.27), KIR2DL5 (0.30), KIR2DS1 (0.19), KIR2DS2 (0.27), KIR2DS3 (0.16), KIR2DS5 (0.17), and KIR3DS1 (0.18) genes. Differences in KIR gene frequency distributions were observed between the Pacific Islands populations and when compared to other populations. Sixty-nine different genotypes were identified, with five genotypes accounting for more then 50% of all genotypes observed. The number of genotypes observed in each population was similar in the Cook Islands, Samoan, and Tokelauan populations (19, 18, and 19, respectively), but 26 different genotypes were observed in Tongans. The putative haplotype A was predominantly observed over haplotype B in all Pacific Islands populations. Significant linkage disequilibrium was observed for a number of KIR gene pairs. Springer-Verlag, 2006 KIR nationallicence NK nationallicence Pacific Islands nationallicence Polynesians nationallicence HLA nationallicence Velickovic Marija Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, 2000, Sydney, NSW, Australia aut Velickovic Zlatibor Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, 2000, Sydney, NSW, Australia aut Dunckley Heather Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, 2000, Sydney, NSW, Australia aut Immunogenetics Springer-Verlag 58/7(2006-07-01), 523-532 0093-7711 58:7<523 2006 58 251 https://doi.org/10.1007/s00251-006-0124-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0124-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Velickovic Marija Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, 2000, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Velickovic Zlatibor Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, 2000, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Dunckley Heather Molecular Genetics Section, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, 2000, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/7(2006-07-01), 523-532 0093-7711 58:7<523 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer