caa a22 4500 467906904 CHVBK 20180406152836.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00251-006-0127-0 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0127-0 Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineages [Elektronische Daten] [Carlos Suárez, Manuel Patarroyo, Esperanza Trujillo, Mónica Estupiñán, Juan Baquero, Carlos Parra, Raúl Rodriguez] One hundred and ten novel MHC-DRB gene exon 2 nucleotide sequences were sequenced in 96 monkeys from three owl monkey species (67 from Aotus nancymaae, 30 from Aotus nigriceps and 13 from Aotus vociferans). Owl monkeys, like humans, have high MHC-DRB allele polymorphism, revealing a striking similarity with several human allele lineages in the peptide binding region and presenting major convergence with DRB lineages from several Catarrhini (humans, apes and Old World monkeys) rather than with others New World monkeys (Platyrrhini). The parallelism between human and Aotus MHC-DRB reveals additional similarities regarding variability pattern, selection pressure and physicochemical constraints in amino acid replacements. These observations concerning previous findings of similarity between the Aotus immune system molecules and their human counterparts affirm this specie's usefulness as an excellent animal model in biomedical research. Springer-Verlag, 2006 Animal models nationallicence New World monkeys nationallicence Molecular evolution nationallicence Molecular convergence nationallicence MHC class II molecules nationallicence MHC-DRB nationallicence Suárez Carlos Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Patarroyo Manuel Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Trujillo Esperanza Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Estupiñán Mónica Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Baquero Juan Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Parra Carlos Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Rodriguez Raúl Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut Immunogenetics Springer-Verlag 58/7(2006-07-01), 542-558 0093-7711 58:7<542 2006 58 251 https://doi.org/10.1007/s00251-006-0127-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0127-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suárez Carlos Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Patarroyo Manuel Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Trujillo Esperanza Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Estupiñán Mónica Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Baquero Juan Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Parra Carlos Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Rodriguez Raúl Fundación Instituto de Inmunmología de Colombia (FIDIC), Carrera 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/7(2006-07-01), 542-558 0093-7711 58:7<542 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 467906904 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer