caa a22 4500 467906939 CHVBK 20180406152837.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00251-006-0128-z doi (NATIONALLICENCE)springer-10.1007/s00251-006-0128-z Comparative molecular and three-dimensional analysis of the peptide-MHC II binding region in both human and Aotus MHC-DRB molecules confirms their usefulness in antimalarial vaccine development [Elektronische Daten] [M. Patarroyo, G. Cifuentes, J. Baquero] A vaccine against malaria is desperately needed, and Aotus monkeys are highly susceptible to experimental infection with malarial parasites. A thorough analysis of this monkey's immune system molecules was thus undertaken in our institute. Cloning and sequencing, followed by three-dimensional analysis, has revealed high homology with some HLA-DRB1 molecules in terms of their peptide binding region pockets. Molecules such as HLA-DRB1*03, 11, 08, and HLA-DRB1*04 are so similar to Aotus MHC-DRB molecules that peptides identified as binding to these molecules and inducing protective immunity in these monkeys could be used in humans without further refinement, while small modifications seem to be needed for those binding to HLA-DRB1*07, HLA-DRB1*15, 16, and HLA-DRB1*10-like molecules, making this New World monkey an excellent model for tailor-made vaccine development, especially against malaria. Springer-Verlag, 2006 Malaria nationallicence Aotus nationallicence MHC-DRB nationallicence P. falciparum nationallicence 1H-NMR nationallicence MHC II-peptide-TCR complex nationallicence Patarroyo M. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera. 50 No. 26-00, Bogotá, Colombia aut Cifuentes G. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera. 50 No. 26-00, Bogotá, Colombia aut Baquero J. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera. 50 No. 26-00, Bogotá, Colombia aut Immunogenetics Springer-Verlag 58/7(2006-07-01), 598-606 0093-7711 58:7<598 2006 58 251 https://doi.org/10.1007/s00251-006-0128-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0128-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patarroyo M. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera. 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Cifuentes G. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera. 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 700 1- Baquero J. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera. 50 No. 26-00, Bogotá, Colombia aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/7(2006-07-01), 598-606 0093-7711 58:7<598 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer