caa a22 4500 467906998 CHVBK 20180406152837.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00251-006-0098-1 doi (NATIONALLICENCE)springer-10.1007/s00251-006-0098-1 Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like [Elektronische Daten] [Chiaki Haruta, Takashi Suzuki, Masanori Kasahara] The jawless vertebrates, represented by hagfish and lampreys, are the most advanced animals that apparently lack T cell and B cell receptors. As such, they offer unique opportunities for understanding the evolution of antigen receptors and variable (V)-type immunoglobulin (Ig)-like domains. In the present study, we describe four hagfish Ig superfamily (IgSF) members carrying V-type domains. None of them appeared to have direct counterparts in jawed vertebrates, indicating that many IgSF molecules have either evolved independently in jawed and jawless vertebrates or diverged to the extent that clear homology is no longer recognizable. One of the members encoded a molecule closely related to the previously described membrane protein designated novel ITAM (immunoreceptor tyrosine-based activation motif)-containing IgSF receptors (NICIR). We show here that NICIR is a polymorphic multigene family with at least three members and is expressed predominantly in peripheral blood leukocytes. Phylogenetic analysis indicates that among known proteins, NICIR is most closely related to the lamprey molecule recently proposed to be a potential ancestor of T cell receptors. Springer-Verlag, 2006 Jawless vertebrates nationallicence NICIR nationallicence ITAM nationallicence ITIM nationallicence Haruta Chiaki Department of Pathology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, North-15 West-7, 060-8638, Sapporo, Japan aut Suzuki Takashi Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies (Sokendai), 240-0193, Hayama, Japan aut Kasahara Masanori Department of Pathology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, North-15 West-7, 060-8638, Sapporo, Japan aut Immunogenetics Springer-Verlag 58/2-3(2006-04-01), 216-225 0093-7711 58:2-3<216 2006 58 251 https://doi.org/10.1007/s00251-006-0098-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00251-006-0098-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haruta Chiaki Department of Pathology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, North-15 West-7, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Suzuki Takashi Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies (Sokendai), 240-0193, Hayama, Japan aut NATIONALLICENCE 700 1- Kasahara Masanori Department of Pathology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, North-15 West-7, 060-8638, Sapporo, Japan aut NATIONALLICENCE 773 0- Immunogenetics Springer-Verlag 58/2-3(2006-04-01), 216-225 0093-7711 58:2-3<216 2006 58 251 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer